(a)
Interpretation:
The method of synthesis of given compound has to be stated with the help of acetoacetic ester synthesis.
Concept introduction:
The final products of acetoacetic ester synthesis are
(b)
Interpretation:
The method of synthesis of given compound is to be stated with the help of acetoacetic ester synthesis.
Concept introduction:
The final products of acetoacetic ester synthesis are ketones, specially substituted derivatives of acetone. In acetoacetic ester synthesis, substituents are added to the enolate ion of acetoacetic ester. Then, hydrolysis takes place followed by decarboxylation to give alkylated derivatives of acetone.
(c)
Interpretation:
The method of synthesis of given compound is to be stated with the help of acetoacetic ester synthesis.
Concept introduction:
The final products of acetoacetic ester synthesis are ketones, specially substituted derivatives of acetone. In acetoacetic ester synthesis, substituents are added to the enolate ion of acetoacetic ester. Then, hydrolysis takes place followed by decarboxylation to give alkylated derivatives of acetone.
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Organic Chemistry (9th Edition)
- The following molecule undergoes an intramolecular reaction in the presence of pyrrolidinium acetate, the protonated form of pyrrolidine. Draw the product of this reaction, assuming that a dehydration reaction takes place.arrow_forwardExplain why pentane-2,4-dione forms two alkylation products (A and B) when the number ofequivalents of base is increased from one to two.arrow_forwardSynthesize the following product via acetoacetic ester synthesis. Use any necessary reagents.arrow_forward
- Using what you know of carbonyl reactions, propose a mechanism for the processarrow_forwardShow how acid derivatives hydrolyze to carboxylic acids under either acidic or basicconditions. Explain why some acid derivatives (amides, for example) require muchstronger conditions for hydrolysis than other derivatives.arrow_forwardWhether you choose to perform an acid-catalyzed or base-catalyzed hydrolysis, the end product should be the same. Predict the product of the following reaction conditions.arrow_forward
- Describe the procedures on how will you prepare an ester.arrow_forwardPropose an efficient synthesis for each of the following transformations. Show all intermediate products, reagents and conditions.arrow_forwardPropose a reaction for the formation of the following products involving esterformation.arrow_forward
- Provide the steps to convert the following aldehyde to the given amine product.arrow_forwardHydroxylamine, H2NOH, has both an OH functional group and an NH2 functional group, so it can feasibly undergo reaction with a ketone or an aldehyde to produce either an acetal or an imine-like compound called an oxime. (a) Draw each of these mechanisms for the reaction of hydroxylamine with acetone. (b) Which is the major product? Hint: Which step decides the outcome?arrow_forwardThe following compound may be synthesized through alkylation of an appropriate enamine with an alkyl bromide, followed by hydrolysis of the resulting immonium ion. Using this strategy, provide the necessary starting materials for the synthesis. (Note that a portion of the starting enamine is given.)arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning