(a)
Interpretation:
The structure of the major product obtained from
Concept introduction:
In Hoffman’s elimination reaction, the less substituted alkene as the more favourable product, whereas according to Zaitsev rule more substituted
(b)
Interpretation:
The formation of the Zaitsev product using stereochemical drawings of the transition states are to be shown.
Concept introduction:
In Hoffman’s elimination reaction, the less substituted alkene as the more favourable product, whereas according to Zaitsev rule more substituted alkenes are considered as more favourable product. The notations
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Chapter 19 Solutions
Organic Chemistry (9th Edition)
- Why can you not use this reaction to make a secondary amine? a) Alkyl halides are weak electrophiles.b) Primary amines are weak nucleophiles.c) The primary amine is too nucleophilic, so over-reaction will occur.d) The secondary amine product is more nucleophilic than the primary amine reactant, so over-reaction will occur.arrow_forwardThe reaction of a nitrile with an alcohol in the presence of a strong acid forms an N-substituted amide. This reaction, known as the Ritter reaction, doesnot work with primary alcohols. a. Why does the Ritter reaction not work with primary alcohols? b. Provide an explanation for why an amide is less susceptible to nucleophilic attack than its corresponding ester.arrow_forward1. State all the products formed from Hofmann elimination of the following amine. Choose the major product. Show the mechanism to obtain the major product. b. C. a. NH₂ Com -CH₂CHCH3 NH₂ NH₂arrow_forward
- 2. Propose all the products formed from Cope elimination of the following amine. Select the major product. Show the mechanism to obtain the major product. a. b. H3C CH3 H₂CH₂C CH3 `N -CH₂CHCH₂ CH,CH,CH3arrow_forwardDraw the major product of this reaction. Ignore inorganic byproducts and the amine side product. 1. NaOH, heat H 2. Neutralizing work-up Drawing Problem 6 Atoms, Bonds and Rings Draw or tap a newarrow_forward1.answer the following questions A. What is reagent used to convert secondary amine to tertiary amine? choices: NH3,SOCL2,H20 and excess NH3,Methylhalide? B. During azide synthesis what is good leaving group? Choices: N3,N2,H20,NH2arrow_forward
- Which of the following functional groups will react faster and at lower conditions to a nucleophilic attack? (you can think of a nucleophilic attack by an amine). O a. Carboxylic Acid o b. Nitrile о с. Асyl Нalide d. Esterarrow_forwarda. The carbonyl group of an amide is less reactive towards nucleophilic substitution reactions because of the so-called amide resonance interaction of nitrogen lone pair (RC=ONR’2 → RC- O=NR2). (Relative reactivities of carbonyl compounds, increasing reactivity: nitriles < amides < esters, acids << ketones < aldehydes < acid chlorides.) However, the amides formed from imidazole (N- acylimidazoles) are highly reactive, and can be used to deliver acyl groups in much the same way as "active" esters, acid anhydrides and acid chlorides. An advantage to using N-acylimidazoles is that the imidazole that is released serves a base so additional base does not need to be added. Imidazole amides have been used in peptide and nucleoside chemistry to attach -amino acid residues to alcohols and amines. Using N-propanoylimidazole and N,N-dimethylpropanamide as examples explain why the imidazole amide is a good acylating agent. b. The amide functional group is one of the more stable carbonyl containing…arrow_forward1. Show mechanisms for the formation of imines as well as their hydrolysis. 1.A. pH 4.5 (HOTS) + H₂O 1.B. NH₂ + H₂O + H-OH₂ NH3 + H₂Oarrow_forward
- H₂N Provide the missing structures. NH2 CH3 1) DCC N. 2) LIAIH 3) H₂O Boc₂O (1 equiv) The aliphatic amine is a stronger base/nucleophile. Whyarrow_forwardBy means of a suitable reaction, show how each of the compounds can be prepared from propionic acid. More than one step may be required. a. methyl propylamine (CH3NHCH2CH2CH3)b. propionyl chloridec. ethyl propionated. propionic anhydridee. N-methyl propionamidearrow_forwardInstructions: Give an acceptable name for eachester. A. CH, CH2)CO,CH, B. COCHỊCH, C. CH₂CH₂CH₂CH₂COOCH₂CH₂CH₂ Instructions: Give the structure corresponding to each name. a. propyl propanoate b. butyl acetate c. ethyl hexanoate d. methyl benzoate Instructions: Give an acceptable name for each amide A. CH₂CH₂CH₂CH₂ NH₂ Instructions: Draw the structure of each amide. A. N,N-dimethylacetamidearrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning