Fundamentals of Anatomy & Physiology (11th Edition)
Fundamentals of Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134396026
Author: Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew
Publisher: PEARSON
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Chapter 19, Problem 28RQ
Summary Introduction

To determine:

The factor that would be deficient in a person with prolonged prothrombin time and a normal partial thromboplastin time.

Introduction:

The clotting of the blood employs three pathways namely the intrinsic pathway, the extrinsic pathway and the common pathway. The extrinsic pathway is the first reacting pathway when a wound is created followed by the intrinsic and common pathway.

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Hyperglycemia associated with diabetes promotes a prothrombotic state by affecting a number of different steps in the clotting pathway. Which of the following would result in more rather than less clotting? Check all that apply. The correct answers reflect the effect of hyperglycemia on the clotting pathway! less conversion of plasminogen to plasmin 7 000000000 abnormally low number of platelets platelets more sensitive to thromboxane A2 elevated conversion of plasminogen to plasmin platelets less sensitive to thromboxane A2 low sensitivity to NO and PGI2 increased prothrombin in the blood increased amount of fibrinogen in the blood less prothrombin in the blood abnormally high number of platelets less fibrinogen in the blood high sensitivity to NO and PGI2
It is known that heparin acts by increasing the activity of antithrombin, causing a conformational change. LMWHs inhibit mainly factor Xa. Although low doses of heparin act primarily by neutralizing factor Xa, at high doses it prevents thrombin-induced platelet activation and prolongs bleeding time. What are major clinical benefits using heparin or LMWHs?
In erythroblastosis fetalis, what combination of blood types between the mother and child would require RhoGam administration?
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