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- Question:- discuss , the relationship between cell viability and cell vitality and cell apoptosis as suggested by neutral red uptake .. Download and read the attached review article (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836099/pdf/EMBR-19-e45440.pdf) titled: Perturbing mitosis for anti-cancer therapy: is cell death the only answer?3. Match question. Based on the figure below, match each label with the corresponding microtubule end or with the corresponding motor protein. Phagocytosis vesicle Hydrolytic enzyme Lysosome Label A B C D D A C B -Microtubule Orientation/motor protein Kinesin + end Dynein - end
- CASE STUDY Cancer-killing bacteria Ralph, a 57-year-old man, was diagnosed with colon cancer.His oncologist discussed the use of radiation andchemotherapy as treatments, both of which can causedebilitating side effects. Ralph decided to explore other optionsand went to a cancer clinic. He learned that researchers in asynthetic biology program were testing the use of geneticallymodified bacterial cells designed to selectively invade specifictumors and kill cancer cells, with no effects on normal cells.Ralph decided to participate and was informed that he wouldbe part of a phase III trial, comparing the effects of the modifiedbacterial cell treatment against conventional chemotherapy.However, as part of the trial, he would be randomly assigned toreceive one or the other treatment. He was disappointed to learnthis, because he assumed that he would receive the bacterialtherapy.Question: Informed consent is legally and ethically required beforesomeone participates in a clinical trial.…1696299405-SBI4U Test... & Preview File Edit View Go Tools Window Help 4 Apoft being educach pr er her s me Dining may waters and the day of the act of DCA I har ful 4 Part-Thinking and Ingairy (15) Camp Bukaryti gone uplates to Prakaryotic game regulation. What the 3. modderpoed for Deplication What they called How are they dont 5 P 5. Dedimxplain the process of transcription. Add 4 Frock point todemontherf of genc 6 P wwwwww V انادا در در درست 1696299405-SBI4U Test 3.pdf Page 6 of 10 days of this course. Please remember the Dropboxes will close 22 280 JAN 22 4. Outline the steps of Frederick Griffith's experiment on mice to demonstrate the transfer of genetic material using Streptococcus pneumoniae. tv V 2 U₁ Search 9 23 Page 5 of 10 80 ((( O Mon Jan 22 6:19 PM All Bookmarks A UQ6. Determine if the level of organization is molecular or cellular. Copy and paste, molecular or cellular in the response box. Cell division is characterized by the separation of centrosomes in the cytoplasm forming spindle. Answer:
- Retinoblastoma: The Hits Just Keep Coming case study Part III – The Second Hit Questions A second hit might occur through epigenetic alterations. In the promoter of RB1, there is a CpG island. Knowing this, how might you predict that a cell could epigenetically inactivate RB1 transcription? A second hit might also occur through loss of heterozygosity (LOH). An example of how LOH may occur by reciprocal crossing over during mitosis is diagrammed in Figure 1 (next page). Discuss and interpret this model with your group. Write a brief explanation of (a) what LOH means and (b) how LOH by mitotic reciprocal crossing over can give rise to a cell lineage with functional loss of the wild-type copy of a tumor suppressor gene. . One of the ways that we know what the RB protein does in cells is that its inactivation is a common priority of tumor-initiating viruses. What advantage would a virus gain by inactivating RB function in its host cell? One example of a DNA virus (a virus that…This is homework not a test! From NTSA case study https://static.nsta.org/case_study_docs/case_studies/cystic_fibrosis.pdf Please help with questions 2, 3 and 4 of part four 2. "The successful use of gene therapy to cure SCID syndrome (2000) is hoped to be a permanent cure for those patients because a good copy of the problem gene was inserted into the patients' blood stem cells in the bone marrow (hematopoietic stem cells). Once white blood cells enter the blood stream they have a limited life span, on the order of a few week to months. The blood stem cells are the cells that create more white blood cells to replace those that are lost. If the gene was only inserted into the circulating mature white blood cells, the patient would only be temporarily cured until those cells were used up or died." The current gene therapy approaches to cure CF involve inserting a functional CFTR gene into the mature epithelial cells of the lungs. In light of the preceding paragraph, do you think that…A. Cyclin Expression Cycle 1. What are the two factors involve in the illustration Cyclin Expression Cycle? 2. Identify the cyclin fluctuation in every stage of the cell cycle. 3. What do you think is the role of cyclin fluctuation at a given stage of a cell cycle? Concentration G₁ cyclin G₁ Phase Cyclin Expression Cycle G₁/S cyclin S Phase S cyclin M cyclin G2 Phase M Phase
- Please answer subquestions 1.a and 1.b Question 1.a: A mutation in MAPK makes it constitutively active. If cells are treated with the control treatment (no EGF) will be observed. When cells are treated with EGF will be observed. A. No proliferation; proliferation B. Proliferation; proliferation C. No proliferation; no proliferation D. Proliferation; no proliferation Question 1.b: In order to prevent a specific event (step), from occurring in a pathway (e.g, the phosphorylation of MAPKK), you should target the portion of the cascade with an inhibitor. A. Downstream B. Extracellular C. Nuclear D. Upstreami want the solution of this assingment please. 1- Typical N-terminal signal sequence ( include description, function, and how they work)2- list address codes for different parts of the cell3- Stop transfer sequence ( description, function, how they work)TRUE OR FALSE 1. A cell may revert back to its normal morphology and physiology after a pathologic adaptation 2. Apoptosis may be normal or pathological 3. Necrosis may be normal or pathological
