Retinoblastoma: The Hits Just Keep Coming case studyPart III – The Second HitQuestions A second hit might occur through epigenetic alterations. In the promoter of RB1, there is a CpG island. Knowing this, how might you predict that a cell could epigenetically inactivate RB1 transcription? A second hit might also occur through loss of heterozygosity (LOH). An example of how LOH may occur by reciprocal crossing over during mitosis is diagrammed in Figure 1 (next page). Discuss and interpret this model with your group. Write a brief explanation of (a) what LOH means and (b) how LOH by mitotic reciprocal crossing over can give rise to a cell lineage with functional loss of the wild-type copy of a tumor suppressor gene. . One of the ways that we know what the RB protein does in cells is that its inactivation is a common priority of tumor-initiating viruses.What advantage would a virus gain by inactivating RB function in its host cell?One example of a DNA virus (a virus that uses DNA, not RNA, as its genetic material) that causes tumors is human papillomavirus (HPV). Do some research and explain how HPV inactivates the RB protein and indicate with which type(s) of cancer it is associated. Don’t forget to cite your sources!

RB1 gene is related to the disease of retinoblastoma. Retinoblastoma is one of the types of cancer…

Answered: second hit might occur through…

Biology: The Unity and Diversity of Life (MindTap Course List)

15th Edition

ISBN:9781337408332

Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Chapter10: Control Of Gene Expression

Section: Chapter Questions

Problem 15SQ

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Retinoblastoma: The Hits Just Keep Coming case study

Part III – The Second Hit

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A second hit might occur through epigenetic alterations. In the promoter of RB1, there is a CpG island. Knowing this, how might you predict that a cell could epigenetically inactivate RB1 transcription?

A second hit might also occur through loss of heterozygosity (LOH). An example of how LOH may occur by reciprocal crossing over during mitosis is diagrammed in Figure 1 (next page). Discuss and interpret this model with your group. Write a brief explanation of (a) what LOH means and (b) how LOH by mitotic reciprocal crossing over can give rise to a cell lineage with functional loss of the wild-type copy of a tumor suppressor gene.

. One of the ways that we know what the RB protein does in cells is that its inactivation is a common priority of tumor-initiating viruses.
What advantage would a virus gain by inactivating RB function in its host cell?
One example of a DNA virus (a virus that uses DNA, not RNA, as its genetic material) that causes tumors is human papillomavirus (HPV). Do some research and explain how HPV inactivates the RB protein and indicate with which type(s) of cancer it is associated. Don’t forget to cite your sources!

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