The omicron variant of SARS-CoV-2 has the amino acid substitution G339D in the spike protein on the virus surface. In cellular fluids at -pH 7 the wild type spike protein has a net negative charge. This substitution will make the spike protein: less negative O absorb UV light more strongly at 280 nm O more negative O more hydrophobic
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- answer doesn't have to be long i just need an explanation, thank you! The whole world right now is concerned (or they should be) about the appearance of new variants of SARS-CoV-2. Among other things, these variant viruses have mutations that change the amino acid sequence of the spike protein on the virus surface. While this is concerning, I would like to propose that there is a limit to how far these mutations can change the spike protein. Why can't there be an endless number of new mutations of this viral protein? How would these amino acid changes affect how the virus works?Research has found that 95% of the particles smaller or equal to the size of the COVID-19 virus will not penetrate through a mask. Based on molecular characteristics of surface molecules of the virus, why might this be?All of the following statements correctly describes the properties of Influenza A virus EXCEPT A-Viral transcription occurs in the nucleus B-Mature virion are released by budding C-Single stranded positive sense RNA virus D-Attaches to cell-surface sialic acid
- The diagram below shows the Covid-19 virus with its spike protein. It also shows the area on the spike protein which binds to the ACE2 receptor (receptor binding domain). Corona Virus Receptor Binding Domain (RBD) Spike Protein In order to get into a cell, the Covid-19 virus needs to bind to the ACE2 receptor. Once bound it is brought into the cell. These receptors are found on cells making up various tissues (oral and nasal mucosa, nasopharynx, lung, stomach, small intestine, colon, skin, lymph nodes, thymus, bone marrow, spleen, liver, kidney, and brain). The symptoms for Covid-19 are linked to the tissue cells the virus infects. To the right is a diagram showing the biding of the spike protein to the ACE2 receptor. SARS-COV-2 Spike (S) Host Cell ACE2 acerCharged spherical viruses have polymer chains attached to their surfaces, e.g. they are ‘PEGelated’ in the language of a synthetic chemist. At what distance of separation does the entropic force due to the chains become significant compared with that due to the inter-virus electrostatic repulsion?The “spikes” in the COVID-19 virus are protein complexes. How important are these spikes in virus infection and its variants?
- Syn5 is a virus that infects photosynthetic bacteria belonging to the genus Synechococcus. The Syn5 virion is icosahedral (660 Å in diameter) with a short tail and an appendage called a horn. The horn is located on a vertex directly opposite the tail. Syn5 follows the typical five steps observed for most viruses when they multiply, and progeny viruses are released when the host lyses. The assembly of Syn5 virions involves several proteins, including capsid proteins, scaffolding proteins, a portal protein, a terminase, tail proteins, and horn proteins. To better understand the assembly of Syn5 virions, scientists used a type of microscopy called Zernike phase contrast electron cryotomography. This type of microscopy improves the contrast typically seen for conventional cryotomography. In their studies, the scientists observed several different developing virus particles in infected cells. The particles were: (1) 660 Å icosahedron containing DNA and having a tail; (2) 660 Å icosahedron…Researchers studying the SARS-CoV-2 virus, also known as COVID-19, have found that the virus is able to circumvent its host cell's normal defenses by leaving the cell via its lyso- somes rather than its normal secretory vesicles, as illustrated in the figure below. endoplasmic reticulum nucleus disrupted lysosomal functions Entry and egress of the SARS-CoV-2 virus A Golgi complex Which of the following best explains their findings? B lysosome (deacidified) С lysosome (acidified) B-coronavirus normal biosynthetic pathway egress via lysosomal trafficking SARS-CoV-2 inhibits lysosomes of its host cells by decreasing the pH within them. SARS-CoV-2 activates lysosomes of its host cells by decreasing the pH within them. SARS-CoV-2 activates lysosomes of its host cells by increasing the pH within them. D SARS-CoV-2 inhibits lysosomes of its host cells by increasing the pH within them.describe the structure of a phospholipid and a phospholipid bilayer for corona virus
- Match the terms 1Genome surrounded by a protein coat 2Functional viral particle capable to infect a new host cell 3Infectious protein 4Infectious agent that needs helper virus for infection 5T4 enzyme that creates holes in the E. coli plasma membrane 6When a temperate phage stimulates their bacterial host tostart producing a toxin (e.g. cholera, shiga) 7Virus that infects bacteria 8Hand N spikes 9Virus without an envelope 10Most common and best studies virulent phage of E. coli 11Protein coat that surrounds viral genome 12:true or false : some viruses can cause cancer [ Choose ] lambda True pathogenic stimulation False Nucleocapsid lysosome Naked virus induction lysozyme Flu viruses tobacco mosaic virus lysogeny capsid Lysogenic conversion Holin Prion satellite bacteriophage (or just phage) T4 Virion StreptococcusAnswer the following and inlcude the references SARS-CoV-2, the virus that causes CoVid-19, belongs to the Coronaviridae family. Viruses under this family have a genome made of single-stranded positive-sense RNA. Is this similar to the viral genome of HIV? If so, do you think that – in theory – they would have similar replication cycles? Do you think that ART combinations/options might help in suppressing the viral replication of SARS-CoV-2? Expound.Indicate whether the following sentences is either True or False and CORRECT the wrong sentences ( please answer the two questions 1 and 2) : 1. Simian Virus 40 (SV40) is an example of is a circular ssDNA belong to Polyomavirus, was first isolated from primary cell cultures derived from rhesus monkey kidneys, and activates p53. 2. SARS-COV-2 is an enveloped, icosahedral virus that is surrounded by a lipid bilayer and causes COVID-19 pandemic .