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1. Choose a specific drug name (NOT A DRUG CLASS) under CELL WALL SYNTHESIS INHIBITORS, and DRAW the structure.
2. Write the Name of the drug, the drug classification, and the brief mechanism of action.
3. Label/Encircle the the
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- CHM3413-Neutral vs lonized... consider the table of drugs shown below and their respective pka value(s). Complete the table by drawing the relevant portion of the drug molecule in its IONIZED form. Indicate whether the ion is the conjugate acid or conjugate base of the neutral drug, if two pka values are listed, then two ionized structures must be drawn. Drug Name: Neutral Form (Neutral) pka from table HA BH+ 5.4 9.5 Baclofen Captopril Ampicillin 3.7 M 9.8 2.5 7.2 Doxycycline 3.4 9.5 7.7 H H₂C HS 1,0 NH₂ Pho OH OH NH H OH S CH₂ NCH₂ OH 0 150 ONN-C H OH 0 CON 6 M lonized Form(s) Is/are the ION(s) a conj. acid or conj, base? CA or CB? % ionized at physiological pH?1. Study the given drug label and answer the question that follows. Show your solution How many total milliliters of diluent are used? What is the final concentration for each drug? a. b. C. How many milliliters are administered to give amoxicillin 500 mg/clavulanate 125 mg? J 343598 00451 AUGMENTIN 250 mg/5 mL 250 mg/5 mL NDC 43598-004-51 Directions for mixing: Tap bottle until all powder flows freely. Add approximately 2/3 of total water for reconstitution (total=65) shake vigorously to wet powder. Add remaining water, again shake vigorously. Dosage: See accompanying prescribing information. Keep tightly closed. Shake well before using. Must be refrigerated. Diecard after 10 days. Your answer AUGMENTIN® AMOXICILLIN/CLAVULANATE POTASSIUM FOR ORAL SUSPENSION When reconstituted, each 5 mL contains: AMOXICILLIN, 250 MG, as the trihydrate CLAVULANIC ACID, 62.5 MG, as clavulanate potassium 75 mL (when reconstituted) DR.REDDY'S Rx only Use only if inner seal is intact. Not contents:…1. Search for a journal article about a certain drug that targets (whether stimulate or block) a specific protein (whether structural, transport, enzyme, or receptor). 2. Using YOUR OWN WORDS answer the following: a. Brief role of the protein in the body b. Disease related to the protein's action c. Mechanism of action of the drug d. Clinical use of the drug 3. Cite your reference by attaching the site's URL.
- Read this article and answer the following question There are 3 different Metformin ER products available: Glucophage XR Glumetza ER Fortamet ER All 3 formulations are available generically but they are not interchangeable as they all use different release mechanisms. Glucophage XR uses a dual hydrophilic polymer system. The drug is slowly released by diffusing through a gel matrix, also known as GelShield diffusion system. Once the tablet is swallowed, the outer layer of the tablet forms a gel layer and the metformin contained within is slowly released. Due to this release mechanism, Glucophage XR can not be cut or split. Glumetza ER uses a mechanism known as gastro-retentive technology (also known as 'Modified Release'). The tablets are designed to remain in the stomach and deliver metformin to the upper GI tract over an extended period of time. Like Glucophage XR, Glumetza ER can not be cut or split. Fortamet ER uses single-composition osmotic technology (SCOT). After…In slides stained with hematoxylin and eosin, the section 2. appears very pink with pale-reddish brown nuclei. Of the following, the most appropriate action is to a. Restain the sections for a longer time in hematoxylin b. Discard and replace the ammonia water c. Replace the hematoxylin with fresh solution d. Change all solutions and restain 13Prepare a schematic diagram and present it. The Figure should illustrate the interactions made between the key components of total and non-specific binding reactions in drug bindings. In preparing this figure, it should reflect on the role of each of the components of the reaction mixtures, and why the subtraction of non-specific from total binding allows us to calculate specific binding. The Figure Legend should be brief but informative.
- Here’s the fractional binding data for 2 different proteins (1 and 2) binding to a Drug D. Which of the following statements is/are true? 1 of 5: Each Protein 1 must only bind 1 molecule of D. 2 of 5: Each Protein 2 must bind 2 or more molecules of D. 3 of 5: Protein 2 binds significantly more D than Protein 1. 4 of 5: Protein 1 and 2 have roughly similar binding affinities for D. 5 of 5: Protein 1 binds faster to D than protein 2 does at low concentrations of D.7. For those drugs that need to be applied with dissolution sustained system, what are their original properties? A. Low aqueous solubility and slow dissolution rate B. High aqueous solubility and slow dissolution rate C. Low aqueous solubility and fast dissolution rate D. High aqueous solubility and fast dissolution rate E. Gaseous state in room temperature with low aqueous solubility 8. Which of the following drug injection methods does involve perpendicularly inserting needle to the patient's body? A. Intramuscular injection B. Intravenous injection C. Subcutaneous injection D. Intradermal injection E. None of the above 9. Which of the following proteins is NOT commonly bound with drug in the bloodstream? A. Albumins B. Globulins C. Fibrinogens D. Antibodies E. None of the above 10. Which of the following events cannot increase the bioavailability of a drug? A. Patients suffer from cirrhosis B. Patients suffer from diarrhea C. Switch to intravenous injection from oral administration…The active drug substance given above contains a carboxylic acid group. Ionizable proton of carboxylic acid (circled in red taken), the pKa value is given as 3.5. This drug must be absorbed through the plasma membrane to pass. The speed of passage through the plasma membrane depends on the polarity of the molecule. Charged and polar molecules are slower than the membrane, neutral and hydrophobic molecules pass more rapidly. Your stomach Its pH is about 1.5 and the pH of the small intestine is about 6.0. whether this drug passes through the stomach or small intestine more into the blood. you wait Explain. In order to get full points, the ionic molecule in the stomach and intestines Compare them in terms of charge and polarity, indicating their state.
- 3. Order: Ranitidine 150 mg PO q12h. Available: Ranitidine 75 mg per tablet. How many tablets per dose should be administered? Show your solution Your answerStudy the given structures below. Which of the following are epimers? H. H- HO- но H- H- он но H- H- OH HO- но- но H- но- -- но -H но- H- но- HHOH CH;OH H- O- -OH- H- OH CH;OH ČH;OH CHOH D-Gul D-Ido D-Gal D-Tal D-Gul and D-Ido D-ldo and D-Gal D-Gal and D-Tal D-Gul and D-Gal None of the given optionsWaRetajarmecology Mcosolt Stream Which the following statements is/ are true regarding the illustrated drug? H,N -COOH 1. The nitrogen plays a role in the mechanism of action unlike chlorine atom. IL. The aromatic ring increases its chemical stability IL It is a prodrug IV.t binds to its target irreversibly V. A phenylalanine moiety can increase the entry into cancer cells