Glutamate, produced in the first transamination reaction, reacts withoxaloacetate in the second transamination reaction to form aspartate thatcan directly enter the urea cycle. In an oxidative deamination reaction, thesame glutamate molecule, through the action of glutamatedehydrogenase along with the presence of the coenzyme NAD+, canproduce an ammonium ion which can also directly enter the urea cycle.The first statement is incorrect while the second statement is correctThe first statement is correct while the second statement is incorrectBoth statements are correctBoth statements are incorrect

During fasting the proteins are cleaved to amino acids some of which are partially oxidized to…

Answered: Glutamate, produced in the first…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Pyruvate can enter the TCA cycle via two enzymatic reactions. Provide a simplified schematic presentation of the TCA cycle to show this. Also indicate how these reactions are regulated.
Consider the following Statements: (1) Citric acid cycle intermediates are often the products from amino acid carbon skeleton degradation. (2) The net effect of transamination is to collect the amino groups from a variety of amino acids into the amino acids glutamate and aspartate. (3) All of the reactions of the urea cycle occur within mitochondria. how many is true
hyperammonemia in patients is compounded by the reality of the normal regulatory controls in the urea cycle. Explain how increased GDH oxidative deamination activity will inhibit the urea cycle.
Isocitrate labeled with 14C at positions 2 and 5 was isolated from cultured liver cells administered [methyl-14C pyruvate] and enough malonate to completely inhibit succinate dehydrogenase. Explain how this can happen.
In the first stage of glycolysis, fructose-1,6-bisphosphate iscleaved to form glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. The latter molecule can then be converted to glyceraldehyde-3-phosphate. Illustrate themechanisms whereby these reactions occur
Discuss the two roles of N-acetylglutamate in the urea cycle. Include relevant chemical structures and reactions. What is the regulatory function of N-acetylglutamate in the urea cycle? What is the other role of N-acetylglutamate in relationship to the urea cycle? Glutamate is the precursor for N-acetylglutamate. How is glutamate involved in the connection between the urea cycle and the CAC?
Explain why, glucose-6-phosphate will prefer to go via the pentose phosphate route. What additional chemical is created by this route, and what role does it play in anabolic pathways?
Hexokinase catalyzes the first step of glycolysis, in which glucose is phosphorylated to form glucose‑6‑phosphate. Give two reasons why a Mg2+ cation is required to facilitate this reaction.
Conversion of amino acid nitrogen into urea by the liver for excretion normally involves all the following enzyme activities EXCEPT O Ornithine transcarbamoylase Carbamoyl phosphate synthetase II Glutamate dehydrogenase Arginase Which of the following statements about the
The peroxisomal enzyme b-ketoacyl–CoA-thiolase does notbind medium-chain acyl-CoA, in contrast to the analogousmitochondrial enzyme. Explain why this phenomenon is anadvantage to the cell.
The same E1-Ez-E3 multienzyme structure found in the pyruvate dehydro- genase and the a-ketoglutarate dehydrogenase complexes is also used in the branched-chain a-ketoacid dehydrogenase complex, which participates in the catabolism of branched chain amino acids. Draw the reaction product when the following substrate is acted on by the branched chain a-keto acid dehydrogenase complex. H,C -C-COo- H,C
After the formation of pyruvic acid it must be converted into Acetyl CoA to enter the Krebs cycle explain the preparatory steps involved in this process.

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