Biochemistry
Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 32, Problem 7P
Interpretation Introduction

Interpretation:

The acetylcholine concentration in the synaptic vesicle needs to be calculated.

Concept Introduction :

The shape of a vesicle is like the shape of a cylinder thus its volume can be calculated as follows:

  V=43πr3

Here, r is radius of the base of the cylinder.

The concentration is calculated as number of moles present in 1 L of the solution.

It is mathematically represented as follows:

  C=nV

From the given number of atoms, the number of moles can be calculated by dividing it with Avogadro’s number which is number of atoms in 1 mol of the substance.

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Based on the same attached figure as in question 1 above (Figure 6.8A-B in your textbook) describing the NMDA receptor, a ligand-gated ion channel for glutamate, why does the current versus voltage response described by the red line go from near zero to a negative current at around -50 mV? (A) Channel pore Glutamate Mg2+ (B) EPSC (PA) 150 100 50 0 -50 -100 -150 Hyperpolarized, Mg2+ blocks ORA Glutamate + Mg2+ 0/ + Na Ca²+ Glutamate, no Mg2+ Depolarized, no Mg2+ block while K+ 100 Mg2+
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