Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 27, Problem 11P
Interpretation Introduction
Interpretation:
The enzyme suitable for such drugs as potential targets should be identified.
Concept introduction:
A catalyst substance may be a molecule that binds to associate protein and reduces its activity. Since obstruction an enzyme's activity will kill an infectious agent or correct a
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a. Ribose-5-phosphate is produced by oxidative decarboxylation of 6-phosphogluconate catalyzed by the enzyme glucose-6-phosphate dehydrogenase.
I. True
II. False
b. The pentose phosphate pathway occurs in the mitochondrion of tissues actively engaged in synthesis of fatty
acids.
I. True
II. False
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The malate aspartate shuttle plays many roles in carbohydrate and amino acid metabolism. Malate can be transferred into the cytosol and interconverted in one enzymatic step to produce [oxaloacetate/glucose/PEP/pyruvate] for use in the pathway of [glycolysis/gluconeogenesis]. A product of the urea cycle, derived from aspartate, can also be converted to malate in one enzymatic step and shuttled into the mitochondria so that the urea cycle product can be used in [fatty acid synthesis/the citric acid cycle/β-oxidation]. The amino group from aspartate can be transferred to [oxalacetate/malate/fumarate/pyruvate/a- ketoglutarate] to form glutamate, which is then transported into the mitochondria. In fact many amino acids are transaminated in this way to form glutamate in the cytosol. In this way, incoming amino acids from the bloodstream can be shuttled into the liver mitochondria as glutamate for conversion by glutamate dehydrogenase to [glutamate/a-ketoglutarate…
Fill in the blanks. Acetaminophen toxicity can occur at high doses in the liver. because ___________ (what type of molecules?) can become saturated and other routes of metabolism take over.Please explain to me what the correct molecule(?) is and why it is correct. I understand that the glucuronidation and sulfation conjugation pathways become saturated, but am not understanding what molecule(s) it is/are that is/are becoming saturated leading to the other routes of metabolism and acetaminophen toxicity.
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- Long explanations are not needed. Direct answers would suffice. a. In the TCA cycle, succinate dehydrogenase channels electrons directly into the electron transfer chain. I. True II. False b. Glucagon is a hormone that activates glycogenolysis. I. True II. Falsearrow_forwardIn 3-4 sentences, briefly explain how lactate is formed, the biological effect of lactate, and explain the biochemical process and path for conversion of lactate. 3. The hormones glucagon, epinephrine, and insulin, can regulate blood glucose levels to protect the brain. For each one provide a short explanation as to whether it raises or lowers glucose how it does this, and indicate whether it is metabolic or catabolic.arrow_forwardPlease clarify GLUCOSE - METABOLISM IN BLOOD, LIVER, PANCREAS, MUSCLE AND BRAIN CELLS DURING "THE FED STATE" AND "FASTING STATE" (AEROBIC AND ANAEROBIC) - UTILIZING KREB'S CYCLE, TCA, ETC, DESCRIBE THE STEPS OF GLYCOLYSIS, GLUCONEOGENISIS, AND CATABOLIC AND ANABOLIC PROCESSES OF GLYCOGEN SYNTHESIS IN THE FED STATE AND FASTING STATE. THIS SHOULD INCLUDE HOROMONAL AND ENZYMATIC ACTIONS IN BLOOD, MUSCLE, LIVER AND BRAIN (NERVOUS TISSUE)?arrow_forward
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