Organic Chemistry (9th Edition)
9th Edition
ISBN: 9780321971371
Author: Leroy G. Wade, Jan W. Simek
Publisher: PEARSON
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Textbook Question
Chapter 24, Problem 24.38SP
Show the steps and intermediates in the synthesis of Leu-Ala-Phe by the solid-phase process.
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Chapter 24 Solutions
Organic Chemistry (9th Edition)
Ch. 24.2A - Draw three-dimensional representations of the...Ch. 24.2A - Prob. 24.2PCh. 24.2B - The herbicide glyphosate (Roundup) kills plants by...Ch. 24.4 - Draw the structure of the predominant form of a....Ch. 24.4 - Draw the resonance forms of a protonated guanidino...Ch. 24.4 - Although tryptophan contains a heterocyclic amine,...Ch. 24.4 - Prob. 24.7PCh. 24.4 - Prob. 24.8PCh. 24.5A - Show how the following amino acids might be formed...Ch. 24.5B - Prob. 24.10P
Ch. 24.5C - Prob. 24.11PCh. 24.5C - Show how you would use a Strecker synthesis to...Ch. 24.6 - Suggest how you would separate the free i-ammo...Ch. 24.7A - Propose a mechanism for the acid-catalyzed...Ch. 24.7A - Give equations for the formation and...Ch. 24.7B - Prob. 24.16PCh. 24.7C - Prob. 24.17PCh. 24.8B - Draw the complete structures of the following...Ch. 24.9C - Prob. 24.19PCh. 24.9C - Prob. 24.20PCh. 24.9C - Prob. 24.21PCh. 24.9E - Prob. 24.22PCh. 24.9E - Prob. 24.23PCh. 24.10A - Propose a mechanism for the coupling of acetic...Ch. 24.10B - Show how you would synthesize Leu-Gly-Ala-Val-Phe...Ch. 24.10B - Show how solid-phase peptide synthesis would be...Ch. 24 - a. The isoelectric point (pl) of phenylalanine is...Ch. 24 - Prob. 24.28SPCh. 24 - Prob. 24.29SPCh. 24 - Prob. 24.30SPCh. 24 - Prob. 24.31SPCh. 24 - Suggest a method for the synthesis of the...Ch. 24 - Prob. 24.33SPCh. 24 - Write the complete structures for the following...Ch. 24 - The following structure is drawn in an...Ch. 24 - Prob. 24.36SPCh. 24 - Prob. 24.37SPCh. 24 - Show the steps and intermediates in the synthesis...Ch. 24 - Prob. 24.39SPCh. 24 - Lipoic acid is often found near the active sites...Ch. 24 - Prob. 24.41SPCh. 24 - Prob. 24.42SPCh. 24 - Prob. 24.43SPCh. 24 - Complete hydrolysis of an unknown basic...Ch. 24 - Prob. 24.45SPCh. 24 - Prob. 24.46SPCh. 24 - Prob. 24.47SP
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- What is signified when an amino acid is designated as an -amino acid?arrow_forwardThe following compound is an intermediate in the biosynthesis of one of the 20 common -amino acids. Which one is it likely to be, and what kind of chemical change must take place to complete the biosynthesis?arrow_forwardWrite all five steps required for the synthesis of Leu-Ala from alanine and leucine.arrow_forward
- In a paragraph form, provide the experimental procedures in the chemical synthesis of protein that contain native serine residues by the reaction of oxazetidine-containing peptides and α-ketoacid.arrow_forwardIf a heptapeptide is made of Y-P-G-P-H-I-L amino acid sequence, what qualitative tests will give positive results when it is subjected to acid hydrolysis?arrow_forwardPlease answer true or false and give a short explanation. Thank you - The coferent of aminotransferases is FAD. - Is phenylalanine a precursor to serotonin?arrow_forward
- In the transamination of an alpha amino acid plus alpha-ketoglutarate, what are the two products of the reaction? R1-CHNH3+COO- + COO-(CH2)2COCOO- ? You do not have to consider stereochemistry. Represent the side group of the amino acid by R1. Be sure to include charges on atoms at pH = 7.arrow_forwardDraw a structural formula for Lys-Phe-Ala. Label the N-terminal amino acid and the C-terminal amino acid. What is the net charge on this tripeptide at pH 6.0?arrow_forwardHumans can synthesize nonessential amino acids from other compounds, whereas essential amino acids must be obtained from the diet. Name the nonessential amino acid that is synthesized in each of the following reactions. COO CH3 COO CH₂ COO™ L CH-NH3* CH₂ CH₂ coo- + 1L de 14 2 COC CH₂ CH₂ coo- COO CH₂ CH₂ doo-arrow_forward
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