Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Textbook Question
Chapter 20, Problem 4P
Understanding an Antidote for Cyanide Poisoning Sodium nitrite (NaNO2) is used by emergency medical personnel as an antidote for cyanide poisoning (for this purpose. it must be administered immediately).
Based on the discussion of cyanide poisoning in Section 20.4. Suggest a mechanism for the lifesaving effect of sodium nitrite.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
WaRetajarmecology Mcosolt Stream
Which the following statements is/ are true regarding the illustrated drug?
H,N
-COOH
1. The nitrogen plays a role in the mechanism of action unlike chlorine atom.
IL. The aromatic ring increases its chemical stability
IL It is a prodrug
IV.t binds to its target irreversibly
V. A phenylalanine moiety can increase the entry into cancer cells
Aromatic compounds are ubiquitous in organic systems. However, many common aromatic compounds are known carcinogens. Discuss the presence of 2 aromatic compounds in our environment (naturally or resulting from human activity). Include the sources of these compounds as well as their biological activity and health impacts.
Think about what part of chymotrypsin, according to our coverage, most contributes to stabilization of the transition state. This contributor is best identified as:
Othe acid/base catalyst
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- For 4-aminosalycilic acid please pick only the second choice phase 2 metabolite per handle present in the drug: OH H,N 4-Aminosalicylic acid OH إختر واحدة أو أكث OH OH NH, HN HO. OH HN HN он HO HO он HQ HO. HO. HNarrow_forwardThe systemic toxicity of Articaine is the greatest among other molecules نوع السؤال: خيار واحد False True hånarrow_forwardHow Research and Development Pharmaceutical Chemist of the Multinational PFIZERaims to discover a new TARGET for the treatment ofdyslipidemias with their respective leading compound.What would be your step-by-step strategy to achieve it?arrow_forward
- -HO- CH3 .N. .CH3 H3C, `N' HO CH3 CH3 Acetylsalicylic acid (Aspirin) O Briefly propose a procedure (or flow chart) on how to separate a mixture of acetaminophen, Acetaminophen Caffeine aspirin and caffeine.arrow_forwardThe additive named that enter into canned beans. However it is an red blood cells. (Do your research for that one). A is used to chemically trap metal ions ofarrow_forwardWhich of these heterocyclic drugs is likely to be the least soluble in water? Use the Fsp³ parameter to decide. OH Tramadol Chemical Formula: C16H25NO2 YOUR OW Pantoprazole Torasemide Chemical Formula: C16H15F2N3O4S Chemical Formula: C16H20N4O3S Temazepam -OH Chemical Formula: C16H13CIN₂O2 Tioconazole Chemical Formula: C16H13C3N₂OS A. Tramadol B. Pantoprazole C. Torasemide D. Temazepam E. Toconazolearrow_forward
- aldotetroses that creates optically active aldaric acidsarrow_forwardExample of a Protein Purification Scheme: Purification of the Enzyme Xanthine Dehydrogenase from a Fungus Volume Total Total Specific Percent Fraction (mL) Protein (mg) Activity Activity Recovery 1. Crude extract 2. Salt precipitate 3. Ion-exchange chromatography |4. Molecular-sieve chromatography 5. Immunoaffinity chromatography 3,800 22,800 2,460 0.108 100 165 2,800 1,190 0.425 48 65 100 720 7.2 29 40 14.5 23 1.8 275 152.108 11 Calculate the specific activity of step#4. Note that percent recovery=% Yield.arrow_forwardYour 64YO 152lb, 5ft 8in female patient daignosed with advanced bladder cancerhas been prescribed ifosamide 1500mg/m2/day IV for 5 days. You calculate the BSA using the Mosteller method as being 1.82m2. Ifosfamide is available in 60mL vials containing 3g of drugs. How many mL will you administer each day?arrow_forward
- A medication order for a patient in the critical care unit of a hospital calls for a continuous intravenous infusion of Isoproterenol, 5 mcg/minute. The standard protocol is to add the contents of a 5-mL ampule of a 1:5000 Isoproterenol injection to 250 mL of dextrose 5% in water. The nurse uses an IV set programmed to deliver 12 gtts/mL. The quantity of Isoproterenol in mcg/mL in the 5-ml ampule The concentration of Isoproterenol in mcg/mL in the infusion The flow rate of the intravenous infusion in gtts/minutearrow_forward6) high abuse potential. Once in the body, amphetamine is metabolized to a series of metabolites. Please fill in the enzyme and type of reaction for each reaction below. Amphetamine is a DEA schedule II controlled substance with a CH, CH, CH, H-C-NH, H-C-NH2 H- C-NH, CH, CH, CH, SCH,CHCOOH NH(C)CH, amphetamine он он CH, CH, H-C-NH2 H-C-NH, CH2 CH, oso, OCH, Enzyme ? Phase I or Phase Il ? 1) 2) 3) 4) 2.arrow_forwardboth emia. If a physician starts a patient on a 5- mg/10-mg dose for 14 days and then raises the dose to 10 mg milli- grams of each drug will the patient take during the first 30 days? /20mg, how many 5. A`patient cuts 100-mg scored tablets to take his 50-mg prescribed daily dose. A prescription for thirty 100-mg tablets costs $45, and a prescription for thirty 50-mg tablets costs $40. The patient asked the pharmacist to weigh an uncut tablet on an electronic balance into two "halves." The uncut tablet was found to weigh 240 mg, and the cut "halves" weighed 125 mg and 115 mg, respectively. (á) How much money did the patient save on a monthly başis by dosing with half tablets? (b) What was the percentage error in the weight of the cut tablets compared with "exact halves"? 6. The recommended dose of memantine HCl (NAMENDA) is:arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Essentials of Pharmacology for Health ProfessionsNursingISBN:9781305441620Author:WOODROWPublisher:Cengage
Essentials of Pharmacology for Health Professions
Nursing
ISBN:9781305441620
Author:WOODROW
Publisher:Cengage
GCSE Chemistry - Acids and Bases #34; Author: Cognito;https://www.youtube.com/watch?v=vt8fB3MFzLk;License: Standard youtube license