Anatomy & Physiology (6th Edition)
6th Edition
ISBN: 9780134156415
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Chapter 15.2, Problem 4CYU
Summary Introduction
To review:
The location of steroid and peptide hormone synthesis in the cell. Identification of the hormone that can be stored in the vesicles and released by exocytosis.
Introduction:
Hormones are known to be the chemical messengers generated by the cells into the extracellular fluids. Such messengers move through the blood and manage the
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Students have asked these similar questions
Comparing cells synthesizing secretory proteins and cells secreting steroid hormones, the cells synthesizing the steroid hormones have:
A) more rough ER.
B) more smooth ER
C) equal amounts of smooth and rough ER
D) equal amounts of smooth and rough ER, but more lysosomes.
E) equal amounts of smooth and rough ER, but fewer lysosomes.
One such laboratory study investigated the binding of a hormone to three different receptor proteins in the cell membrane. The data collected are shown in the table below:
1) Provide a brief explanation as to why ligand binding to proteins must be a reversible process.
2) Calculate the dissociation constant (Kd) for the hormone binding to each of the three proteins.
3) Which of the proteins demonstrate the tightest/strongest binding of the hormone? Which demonstrates the least tight binding of the hormone? What is the basis for your answer?
Can I get help please with this question?
Two mutations have occurred to proteins within the glucagon signaling pathway:
A) The glucagon receptor has a mutation. This mutation causes this GPCR to always have a conformation that will induce nucleotide exchange for any associated heterotrimeric G proteins, even without glucagon binding to the receptor.
B) The alpha subunit of the heterotrimeric G protein has a mutation. This mutation causes the Gαarginine finger to always be in a position to properly order the catalytic residues within the Gαsubunit to promote catalysis.
Question: What will the combined effect of both mutations be on the signaling pathway and what is the mechanistic reason for this effect?
Chapter 15 Solutions
Anatomy & Physiology (6th Edition)
Ch. 15.1 - Prob. 1CYUCh. 15.1 - Prob. 2CYUCh. 15.1 - What is the difference between a hormone and a...Ch. 15.2 - Prob. 4CYUCh. 15.3 - Prob. 5CYUCh. 15.3 - Consider the signaling mechanisms of water-soluble...Ch. 15.4 - What are the three types of stimuli that control...Ch. 15.5 - Prob. 8CYUCh. 15.6 - Prob. 9CYUCh. 15.6 - Prob. 10CYU
Ch. 15.6 - List the four anterior pituitary hormones that are...Ch. 15.7 - Prob. 12CYUCh. 15.8 - What is the major effect of thyroid hormone?...Ch. 15.8 - Name the cells that release each of the three...Ch. 15.9 - List the three classes of hormones released from...Ch. 15.10 - Synthetic melatonin supplements are available,...Ch. 15.11 - Which hormone does the heart produce and what is...Ch. 15.11 - Prob. 18CYUCh. 15.11 - MAKING connections Diabetes mellitus and diabetes...Ch. 15.11 - MAKING connections Which of the two chemical...Ch. 15 - The major stimulus for release of parathyroid...Ch. 15 - The anterior pituitary secretes all but (a)...Ch. 15 - A hormone not involved in glucose metabolism is...Ch. 15 - Parathyroid hormone (a) increases bone formation...Ch. 15 - Choose from the following key to identify the...Ch. 15 - Prob. 6MCCh. 15 - Testosterone is to the male as which hormone is to...Ch. 15 - If anterior pituitary secretion is deficient in a...Ch. 15 - If there is adequate carbohydrate intake,...Ch. 15 - Hormones (a) are produced by exocrine glands, (b)...Ch. 15 - Some hormones act by (a) increasing the synthesis...Ch. 15 - Absence of thyroid hormone would result in (a)...Ch. 15 - Medullary chromaffin cells are found in the (a)...Ch. 15 - Atrial natriuretic peptide secreted by the heart...Ch. 15 - Prob. 1SAQCh. 15 - Which type of hormone receptorplasma membrane...Ch. 15 - Prob. 3SAQCh. 15 - Name two endocrine glands (or regions) that are...Ch. 15 - The anterior pituitary is often referred to as the...Ch. 15 - The posterior pituitary is not really an endocrine...Ch. 15 - Endemic goiter is not really the result of a...Ch. 15 - How are they hyperglycemia and lipidemia of...Ch. 15 - Name a hormone secreted by a muscle cell and two...Ch. 15 - We have a new patient to consider today. Mr....Ch. 15 - We have a new patient to consider today. Mr....Ch. 15 - We have a new patient to consider today. Mr....
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- The binding of small amounts of hormones to target cell receptors triggers an intricate signal cascade. Why is the signal cascade necessary? Why not just have a simple molecularmechanism between the hormone and cellular effect?arrow_forwardA study is conducted to assess the molecular mechanisms of hormone X. A radioactively labeled form of this hormone is incubated with human cells in tissue culture for 30 minutes, and then incubated briefly with a cross-linking agent. The plasma membrane, cytosolic, and nuclear fractions are isolated from the cell lysate, and the subcellular proteins are separated from these fractions by gel electrophoresis. The only protein bound to the labeled hormone is identified in the new clear fraction. Hormone X is most likely which of the following? Epinephrine Glucagon Growth hormone Insulin Thyroxinearrow_forwardWhat is the cell found in tissues where the hormone produced leaves behind a C peptide during proteolytic activation?arrow_forward
- Progesterone is a steroid hormone that is produced by the placenta during pregnancy. Based on its structure (shown below), explain why progesterone’s effects are mediated by a receptor located inside the cell rather than on the cell membrane.arrow_forwardSteroid hormones are required by the body at puberty and into adolescence to regulate growth and cell division at more rapid pace than in later life. This regulation occurs via their interaction with cellular receptors and the signaling cascades/pathways that follow. Describe for me the difference between the two major classes of steroids, anabolic and catabolic steroids. What might you expect the result of signaling cascades to be in cells receiving either anabolic or catabolic “signals”? (B) At some point in late adolescence, steroid production decreases by almost 100 fold, as we transition into “adulthood”. Why might we wish to stop these signals from constantly being in our blood stream, (like, Say, between 17-24 years of age)? What result might these steroids have on cancer cells where abhorrent signaling is already causing an increased rate of cell division/growth? Could steroid use result in Cancer?arrow_forwardAs an intracellular messenger molecule, explain the role of Ca2+ ion? (( cell signaling book , metabolism book )arrow_forward
- The hormones known as "catecholamines" (adrenaline, noradrenaline, and dopamine) are not lipid-soluble. Therefore their receptor sites are: O a) On the inside of the plasma membrane O b) On the outside of the plasma membrane O c) In the cell cytoplasm O d) In the cell nucleusarrow_forwardWhich of the following occurs once the lipid-soluble hormone diffuses across the plasma membrane into the cytoplasm? Identify the most correct answer. O The hormone binds directly to the DNA in the nucleus. O The hormone binds to its specific receptor in the plasma membrane. O The hormone binds to its specific receptor and another receptor binds forming a dimer. O The hormone binds to another transport protein in the cytoplasm. Save for Later 80 F5 F6 F7 Attempts: 0 of 3 used F8 F9 Submit Answer F10arrow_forwardWhich of the following statements is true? Question 2 options: a) All cells will respond to the hormonal signal because hormones are broadcast throughout the body. b) The regulation of inflammatory responses at the site of an infection is an example of paracrine signaling. c) Paracrine signaling involves the secretion of stimuli into the bloodstream for distribution throughout the organism. d) The axons of neurons typically signal target cells using membrane-bound signaling molecules that act on receptors in the target cells.arrow_forward
- Estrogen receptor antagonists inhibit tumors by: 1) blocking estrogen binding to receptors 2) binding cell-surface receptors 3) stimulating intracellular receptors 4) binding HER2 receptors and keeping agonists from bindingarrow_forwardOne such laboratory study investigated the binding of a hormone to three different receptor proteins in the cell membrane. The data collected are shown in the table below Which of the proteins demonstrate the tightest/strongest binding of the hormone? Which demonstrates the least tight binding of the hormone? What is the basis for your answer?arrow_forwardN Signal Sequence The schematic above depicts a protein with the indicated signaling sequences along its length. Based on these signaling sequences what type of protein is this? N-X-S/T there is not enough information to determine A secreted peptide hormone A lysosomal hydrolase A glycoproteinarrow_forward
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