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Familial polydactyly is an autosomal dominant trait that results in extra fingers or toes. An affected
woman and a normal man have a normal son. This couple wants to have 4 more children. What is the
probability that 3 of the children are polydactyl
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- Neurofibromatosis-1 (NF1) is an autosomal dominant disorder where tumours form in the base layer of the skin or in nerve tissues. What is the probability that individuals II-1 and II-2 will have a genetic son with NF1? Find the image attached.A couple is both heterozygous for the autosomal recessive disease cystic fibrosis (CF). What is the probability that their first child will either be a girl or have CF but not both?Hemophilia is a sex-linked recessive trait. A male hemophiliac and phenotypically normal female have a son with hemophilia. They would like to have one more child. What is the probability of having a child without hemophilia? Explain using a Punnett square. Is it possible for a girl to be born with hemophilia? Explain.
- Cystic fibrosis (CF) is an autosomal recessive trait (a). Assume that Emily (who has CF) decides to have children with a man who does not have CF and who is not a carrier of CF. What are their genotypes, and what is the probability that they will have a child who is a carrier for CF?You met with two parents whose first child has sickle cell anemia. (The parents show no signs of the disease themselves). The mother comes to you in the third month of her second pregnancy, and wants to know if this child will also inherit the disease. As a genetics counselor, you are ready to evaluate this couple’s case by doing the following:1. Determine what the genotype of each parent is. Is this disease autosomal or sex-linked? Dominant or recessive?Albinism is an autosomal recessive condition characterized by absence of melanin pigment from the skin, eye and hair. Two carriers of albinism marry and plan to have FIVE children. Assume a 1:1 sex ratio. What is the probability that at least 3 children will be normal?
- Both have a genetic disorder, but they already have one child who does not have the disorder. They would like to have more children and were told by a friend that since their first child was normal their future children would be normal as well. Explain to them the probability of future offspring being normal or having the disease (assume that this is an autosomal disease). Be sure to tell them whether the disease is brought about by a dominant or recessive allele and what fraction of their children (if any) could be carriers for the disease.A young couple went to see a genetic counselor because each had a sibling with cystic fibrosis. (Cystic fibrosis is a recessive disease, and neither member of the couple nor any of their four parents is affected.) What is the probability that the female of this couple is a carrier? What are the chances that their child will have cystic fibrosis? 3. What is the probability that their child will be a carrier of the cystic fibrosis disease allele?A recently married couple are both heterozygous for cystic fibrosis, a recessive genetic disorder. They would like to start a family and would like to have two children. What is the probability that both their first and second child would have cystic fibrosis?
- Two normal parents have a child with cyatic fibrosis. Would this be an autosomal dominant or autosomal recessive disorder? What is the chance that their next child will have cystic fibrosis?Frank and Susan both have freckles but they're firstborn son Lawrence does not demonstrate the characteristics. What are the most likely genotype of Frank Susan and Lawrence?Cystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF. a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF? b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected? c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?