1. The figure below shows a pedigree examining the presence of a genetic disorder across multiplegenerations of a family. Based off this figure, answer the following questions prompted:||IV391052C611T71281513161417d) What is the genotype for individual #4 in this family pedigree?|||c) Why are no family members identified as a carrier of this genetic disorder?Figure Keya) Using the figure key provided, identify which members of this family are affected by this geneticdisorder in each generation. (Be sure to include sex and generation number for each individualidentified).b) Is this an autosomal recessive, autosomal dominant, or sex-linked genetic disorder? Explain.Unaffected FemaleUnaffected MaleAffected Female|||Affected MaleFemale CarrierMale Carrier

Name: 1. The figure below shows a pedigree examining the presence of a gene
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Description: 1. The figure below shows a pedigree examining the presence of a genetic disorder across multiplegenerations of a family. Based off this figure, answer the following questions prompted:||IV391052C611T71281513161417d) What is the genotype for individ

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The figure below shows a pedigree examining the presence of a genetic disorder across multiple generations of a family. Based off this figure, answer the following questions prompted: 11 III 10 11 12 13 14 Figure Key Unaffected Female Unaffected Male Affected Female Female Carrier Male Carrier

The figure below shows a pedigree examining the presence of a genetic disorder across multiple generations of a family. Based off this figure, answer the following questions prompted: 11 III 10 11 12 13 14 Figure Key Unaffected Female Unaffected Male Affected Female Female Carrier Male Carrier

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter6: Cytogenetics: Karyotypes And Chromosome Aberrations

Section: Chapter Questions

Problem 2QP: Given the karyotype shown at right, is this a male or a female? Normal or abnormal? What would the...

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a) What is the mode of inheritance in the following pedigree for the disease trait (autosomal dominant or recessive?) b) What are the possible genotypes for each individual in the pedigree? (Hint: You can use “A” for dominant allele and “a” for recessive allele)
Ensure answers are clearly labelled a) & b). a) Consider the following pedigree. The solid symbols represent affected individuals. Which of the following is / are possible genotypes for IV-2 with respect to this disease? Please type 1 - 4, and indicate yes or no only for each I II III 1 IV 3 V 1 1. ХАха 2. хаха 3. Aa 4. A1Α2 b) Genes A, B and C are on the same chromosome linked in cis (coupling) conformation. A is 23 cM from B, and B is 17 cM from C. The distance between A and C is 40 cM. The coefficient of coincidence is 0.75 for a trihybrid test cross. How many individuals with the genotype aaBbcc do you expect to see among the offspring of the cross if 1000 offspring are obtained? Please show your calculations and round your answer off to the nearest whole number.
6) For the pedigree shown below, answer the following questions. I II III a) What type of inheritance is shown? Explain how you know. b) The genotype of individual I -2 is The genotype of individual II -1 is
1. The pedigree below shows the incidence of rare, autosomal dominant disorder called Ehlers-Danlos disease. The pedigree covers three generations of a particular family and also shows individual genotypes at a potential marker locus (M). a) Indicate the phase of all gen II and III individuals. DdM1M3 ddM2M6 II DDM3M6 ddM4M5 III DdMзM4 DdMЗМ5 DDM3M4 ddM3M5 DDM3M4 ddM5M6 DDM3M4 ddM4M6 ddM5M6 ddM5M6 b) Which, if any, of the gen III individuals are recombinants? c) Calculate the LOD score as a test of physical linkage between the marker (M) and the disease locus. d) What do you conclude about linkage between D and M?
Niemann Pick Type C disease is a recessive disorder that causes the accumulation of cholesterol and other lipids in lysosomes, ultimately affecting both the liver and the nervous system. Below are the genotypes and phenotypes of offspring of a family with a history of Niemann Pick. 7 NN ( all normal phenotype) 3 Nn (all normal phenotype) 4 nn (1 early onset dementia, 1 mid-life onset dementia, 2 late-onset dementia). From this information, Niemann-Pick disease is an example of: A) variable expressivity B) incomplete dominance C) incomplete penetrance D) variable expressivity and incomplete penetrance E) multiple alleles
PKU is an inherited disease caused by a recessive allele. If a woman and her husband, who are both carriers (heterozygotes) for the disorder, have three children, what is the probability of each of the following? a) All three children are of normal phenotype. b) All three children have the disease. c) Any 2 of the three children have the normal phenotype.
What the grandparents' genotypes are? Why doesn’t the father (II-1) have the disease breast cancer? What is the formal name for an individual having the gene but not showing the trait? For this particular family, what is the recombination rate between the D17S74 marker and the breast cancer gene?
Cystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF. a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF? b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected? c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?
Ensure answers are clearly labelled a) & b). a) Consider the following pedigree. The solid symbols represent affected individuals. Which of the following is / are possible genotypes for II-2 with respect to this disease? Please type 1 - 4, and indicate yes or no only for each. II III 1. xAxa 2. xaxa 3. Aa 4. AA2 b) Genes A, B and C are on the same chromosome linked in cis (coupling) conformation. A'is 16 cM from B, and B is 22 cM from C. The distance between A and C is 38 cM. The coefficient of coincidence is 0.55 for a trihybrid test cross. How many individuals with the genotype AabbCc do you expect to see among the offspring of the cross if 1000 offspring are obtained? Please show your calculations and round your answer off to the nearest whole number.
A man of blood group A is being sued by a woman of blood group B for paternity. The women’s child is blood group O. A) Is this man the father of this child? Explain. B) If this man actually is the father of this child, specify the genotypes of both parents. C.) If it was impossible for this group A man to be the father of a type O child, regardless of the mother’s genotype, specify his genotype. D.) If a man was blood group AB, could he be the father of a group O child? Why/why not?
1. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X- linked recessive and b) X-linked dominant in order to determine what is the mode of transmission of this trait. Disease allele = XA or Xa, depending on mode of transmission of the disease respectively. *Unaffected/No carrier-Normal Unaffected X chromosome = X I 11 * 1 2 1 2 3 a) X-linked recessive 11x12 III 2 genotype (circle one): XY 4 XAXA 2 3 5 Xaya *4 6 7 8 b) X-linked dominant 11x12 XAY Xay
II. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X- linked dominant and b) X-linked recessive in order to determine what is the mode of transmission of this trait. Disease allele = XA or Xª, depending on mode of transmission of the disease respectively. *Unaffected/No carrier-Normal Unaffected X chromosome = X I || III 1 1 2 a) X-linked recessive 9 III 6 genotype (circle one): XX * 1 2 3 11x12 4 ΧΑΧΑ 2 5 xaxa *4 6 7 8 b) X-linked dominant 11 x 12 오 XAX хах