1. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X-linked recessive and b) X-linked dominant in order to determine what is the mode of transmission ofthis trait. Disease allele = XA or Xa, depending on mode of transmission of the disease respectively.*Unaffected/No carrier-NormalUnaffected X chromosome = XI11* 12123a) X-linked recessive 11x12III 2 genotype (circle one): XY4XAXA235Xaya*4678b) X-linked dominant 11x12XAYXay

Name: 1. Given the following pedigree below, use Punnett squares for each o
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Description: 1. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X-linked recessive and b) X-linked dominant in order to determine what is the mode of transmission ofthis trait. Disease allele = XA or Xa, depend

The mode of inheritance is the pattern by which the trait or a disorder, which is passed from one…

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Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X- linked recessive and b) X-linked dominant in order to determine what is the mode of transmission of this trait. Disease allele = XA or Xª, depending on mode of transmission of the disease respectively. Unaffected X chromosome = X *Unaffected/No carrier-Normal 11 d 1 * 1 1 2 a) X-linked recessive 9 III 2 genotype (circle one): XY 2 3 11x12 4 ΧΑΧΑ 2 3 5 Xaya *4 6 7 8 b) X-linked dominant 11x12 오 XAY Xay

Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X- linked recessive and b) X-linked dominant in order to determine what is the mode of transmission of this trait. Disease allele = XA or Xª, depending on mode of transmission of the disease respectively. Unaffected X chromosome = X Unaffected/No carrier-Normal 11 d 1 1 1 2 a) X-linked recessive 9 III 2 genotype (circle one): XY 2 3 11x12 4 ΧΑΧΑ 2 3 5 Xaya *4 6 7 8 b) X-linked dominant 11x12 오 XAY Xay

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter4: Pedigree Analysis In Human Genetics

Section: Chapter Questions

Problem 10QP: A proband female with an unidentified disease seeks the advice of a genetic counselor before...

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II. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X- linked dominant and b) X-linked recessive in order to determine what is the mode of transmission of this trait. Disease allele = XA or Xª, depending on mode of transmission of the disease respectively. *Unaffected/No carrier-Normal Unaffected X chromosome = X I || III 1 1 2 a) X-linked recessive 9 III 6 genotype (circle one): XX * 1 2 3 11x12 4 ΧΑΧΑ 2 5 xaxa *4 6 7 8 b) X-linked dominant 11 x 12 오 XAX хах
1. The figure below shows a pedigree examining the presence of a genetic disorder across multiple generations of a family. Based off this figure, answer the following questions prompted: || IV 3 9 10 5 2 C 6 11 T 7 12 8 15 13 16 14 17 d) What is the genotype for individual #4 in this family pedigree? ||| c) Why are no family members identified as a carrier of this genetic disorder? Figure Key a) Using the figure key provided, identify which members of this family are affected by this genetic disorder in each generation. (Be sure to include sex and generation number for each individual identified). b) Is this an autosomal recessive, autosomal dominant, or sex-linked genetic disorder? Explain. Unaffected Female Unaffected Male Affected Female ||| Affected Male Female Carrier Male Carrier
1. The pedigree below shows the incidence of rare, autosomal dominant disorder called Ehlers-Danlos disease. The pedigree covers three generations of a particular family and also shows individual genotypes at a potential marker locus (M). a) Indicate the phase of all gen II and III individuals. DdM1M3 ddM2M6 II DDM3M6 ddM4M5 III DdMзM4 DdMЗМ5 DDM3M4 ddM3M5 DDM3M4 ddM5M6 DDM3M4 ddM4M6 ddM5M6 ddM5M6 b) Which, if any, of the gen III individuals are recombinants? c) Calculate the LOD score as a test of physical linkage between the marker (M) and the disease locus. d) What do you conclude about linkage between D and M?
2. Hemophilia is an X linked recessive trait. There is a woman who is a carrier for hemophilia and marries a man with hemophilia. a) Complete the Punnett Square (it is a google drawing so you will have to double click it to go to the drawing and type in and around the square. Hold the CONTROL (or Command) button and press the PERIOD button to write a superscript/exponent.) b) What are the possible genotypes of the children? c) Could any of their children have hemophilia? If so, would the child be male or female? Explain your reasoning.
10. Examine the pedigree from a family with a genetic disease and answer the questions below: 1:1 1:2 I1:1 II:2 I1:3 Il:4 II:5 I1:6 II:1 III:2 II:3 I:4 III:5 II:6 a) Does this pedigree indicate autosomal dominant, recessive or sex- linked type of inheritance? Give reasons for your choice. b) Assuming that B and b are the normal and mutant alleles respectively, what would be the genotypes of the individuals: II.1, II.2 and III.3 ? c) Individual II.3 requested genetic counselling. What is the probability that her child would be affected. Explain why.
6. a) Which individual (what number) in the pedigree below rules out X-linked dominant? b) Which individual in the pedigree below rules out autosomal recessive? Briefly explain why. c) Which individual in the pedigree rules out X-linked recessive? Briefly explain why. 1 2 II 1 2 II 1 2 3 4 5 6 7 8 IV 1
1. Please consider the following pedigree. I 1 2 II 1 a) Assume that colour is controlled by a single sex-influenced gene where orange is expressed preferentially in females. Individuals I-1 and I-2 are homozygous for orange and blue respectively. Which individual/s in generation II will be blue? b) If colour is a controlled by cytoplasmic DNA, which individual/s in generation II will be orange?
1. In the pedigree below, Use "A" for the allele associated with the dominant phenotype, and lowercase "a" for the allele associated with the recessive phenotype. Determine what is the most likely mode of inheritance of this disease (whether it is inherited as the result of an autosomal dominant or autosomal recessive trait). Write the most probable genotype for each individual based on the mode of inheritance you have determined. Show how all the partners are crossed and the expected offspring produced (You may use Punnett Square) 1 dró || IV
6) For the pedigree shown below, answer the following questions. I II III a) What type of inheritance is shown? Explain how you know. b) The genotype of individual I -2 is The genotype of individual II -1 is
1. A) Apply the concept of sex linkage to explain why color blindness is more prevalent in men than in women. B) Mary is concerned that she may be a carrier for hemophilia, a sex-linked condition located on the X chromosome. Mary is married to John, who doesn't have hemophilia. Assuming Mary is a carrier, what are the genotype ratios expected for Mary and John's kids (specify for boys and for girls)? C) Mary and John have 2 boys, none of them has hemophilia. Can we use this fact as proof that Mary does not carry the allele for hemophilia? Explain your argument.
1. Please consider the following pedigree. I 1 II 1 a) Assume that colour is controlled by a single sex-influenced gene where green is expressed preferentially in males. Individuals I-1 and I-2 are homozygous for red and green respectively. Which individual/s in generation II will be red? b) If colour is a controlled by cytoplasmic DNA, which individual/s in generation II will be green?
Using designations "Group A", “Group B," etc., organize the mutant strains into complementation groups. If the result of any cross does not fit your groupings, indicate which cross(es) you have excluded. Consider the consequence if one of the mutations was dominant. You should see that complementation tests could not be used to provide information about dominant mutations. a) If a mutation were dominant, how would the diploid be affected? What effect would this have on the determination of your complementation groups? b) How would you test if any of these trp¯ mutations were dominant?