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- Please label the tetrad type in the table as PD (parental ditype), NPD (non parental ditype) or T (tetratype) and answer the following questions a) Are the genes linked? Please explain SPECIFICALLY how you can distinguish between linked and unlinked genes in this instance. b) If the two genes are linked, calculate the % recombination between ser and thr. Show the formula used, as well as all of your calculations. c) Draw a single map illustrating the arrangement of the two genes on the chromosome with respect to each other and to the centromere of the chromosome. Make sure to map ALL three distancesA trihybrid individual with the genotype AaDdEe is testcrossed with an aaddee individual. The resulting offspring are as follows: ADe 7 aDE 157 AdE 688 ade 153 ADE 125 aDe 680 Ade 182 adE 8 Total = 2000 a) b) Determine the allele arrangement and gene order in the trihybrid parent. Give your answer using the PQr/pqR notation. Draw a chromosome map for these genes. Give your map distances to two decimal places. (Use underline or underscore (_) to draw the line for the map)In tomato the mutant genes o (oblate=flattened fruit), p (peach=hairy fruit) and s (compound inflorescence) were found to be in chromosome 2. The test cross results are: 73 110 + 348 2 2 + 306 p 96 63 a) Construct the linkage map b) What are the genotypes of the homozygous parents used in making the F1 heterozygote? c) Compute for the coefficient of coincidence. O o O O +
- Alleles of genes A and B were analyzed in Neurospora according to the cross shown below. Ordered tetrads are summarized in each horizontal row with the number of tetrads in each category listed alongside. A) Analyze the data to determine the recombination frequency (RF) between A and B, along with any additional information that is available from this data. B) Draw a map of the chromosome or chromosomes with appropriate map distances. C) Use the Perkins formula to reanalyze any relationship between A and B.Consider the following two nonhomologous wildtype chromosomes, where letters or numbers represent genes, the "-" represents the centromere of each chromosome, and chromosomes are shown on separate lines. ABCDE-FGHIJK 123-45678 Identify the type of rearrangement shown in each of the following (A-C) and then identify whether it is balanced or unbalanced. Assume that the individual is diploid and heterozygous for the rearrangement. A. ABCDE-FGHIJKGH 123-45678 Rearrangement: [Select] • Balanced or Unbalanced: [Select] B. ABCDGF-EHIJK 123-45678 Rearrangement: [Select] Balanced or Unbalanced: [Select]Consider the first category of test-cross offspring shown in figure 8.2 (+b, LS). Consider also that the parents of the heterozygous female flies in the test cross had the following genotypes: bb, SS, and +, LL. A. What would be the physical phenotype of these flies? B. If PC was conducted with the DNA of one of these flies using the primers for the molecular marker, what would be the appearance of the bands on an electrophoresis gel with the PC products? C. If the gene for black body and the locus for the molecular marker (L long or S short) were unlinked, what proportion of the test-cross progeny would be black flies that are heterozygous for the molecular marker? What proportion would be flies with normal body color, which are homozygous for one form of the molecular marker? D. If the gene for black body and the locus for the molecular marker were linked, how would the proportion of flies be different?
- a) Explain why when a chiasma is formed, only 50% of the meiotic products will be of recombinant type. b) Determine the sequence of the three genes (y, cl and vg) that are linked on a chromosome based on the genetic distances provided below: y- vg 43 y- cl vg – cl 5 38A trihybrid individual with the genotype QqRrTt is testcrossed with a ggrrtt individual. The resulting offspring are as follows: QrT QRt Qrt 11 grT 76 50 qRT 357 343 qrt 78 QRT 76 qRt Total = 1000 Determine the allele arrangement and gene order in the trihybrid parent. Give your answer using the AbC/aBc notation. Draw a chromosome map for these genes. Give your map distances to one decimal place. (Use underline or underscore (_) to draw the line for the map) a) b)Consider a maize plant: Genotype C/cm ; Ac/Ac+ where cm is an unstable colorless allele caused by Ds insertion. What phenotypic ratios would be produced and in what proportions when this plant is crossed with a mutant c/c Ac+/Ac+? Assume that the Ac and c loci are unlinked, that the chromosome-breakage frequency is negligible, and the C allele encodes pigment production.
- As a graduate student, you join a lab and you are looking through some old notebooks. You find a linkage map someone has drawn. G--15 mu-----T----10 mu-------B If you plan to complete a test cross with a GtB/gTb male, A) What are all of the expected progeny genotypes? B.) How many of each genotype would you expect if you collected 1000 progeny?a) Are the genes linked? Please explain SPECIFICALLY how you can distinguish between linked and unlinked genes in this instance. b) If the two genes are linked, calculate the % recombination between ser and thr. Show the formula used, as well as all of your calculations. c) Draw a single map illustrating the arrangement of the two genes on the chromosome with respect to each other and to the centromere of the chromosome. Make sure to map ALL three distances.Below is a pedigree from one family (two parents and eight children). Four of the children (indicated by shaded shapes) are affected with a serious disease with an unknown genetic cause. a) For the disease, what pattern of inheritance (autosomal/sex-linked, recessive/dominant) is exhibited by this pedigree? b) Linkage analysis of the disease to a series of VNTR polymorphisms on human chromosome 5 is shown above. Is there evidence for linkage between the disorder and the VNTR? Briefly explain your answer.