A) Using all available information, what is the correct inheritance pattern of this trait? Why? B) Draw the pattern that would result for DNA amplification of individual I-2 in the empty lane of the gel. C) What is the probability if individual IV-1 mates with an affected male that their offspring will be an affected female? D) What is the genotype of individual II-2?
PLEASE ANSWER THE FOLLOWING LETTERS: a,b,c, and d
Examine the pedigree of the McGraw family shown below. Certain individuals in this family are affected by a brain condition that makes them more susceptible to vertigo. As a genetic counselor, you interview the family and draw DNA samples. You discover that the condition is caused by a mutation that changes the sequence 5’GCATTC3’ to 5’GAATTC3’ introducing an EcoRI cut site. You decide to amplify a 1200bp fragment from the DNA that spans this mutation and then digest it with EcoRI. You run the results on a gel next to a marker that shows bands at 2000bp, 1200bp, 900bp, 800bp, and 400bp. Some individuals from the pedigree are identified on the gel.
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