From the data, what can you conlucde about the effect of this mutant?
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![A physician has identified
a mutant version of PAH
that causes a mild form of
PKU. You measure the
activity of PAH as you
increase the concentration
of BH4. Data are shown for
the WT (red) and mutant
(blue) forms of PAH in the
graph below.
Activity uMol L-Tyrosine/min_mg)
2.0
1.5-
0.5-
0.0-
50
100
[BH4] (UM)
150
200
From the data, what can
you conlucde about the
effect of this mutant?](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F5c618048-b4b5-4c2a-a8b3-e4d9ef6f9c6a%2F465a6e17-829b-4455-b663-603631c94fe5%2Fl0ojleu_processed.jpeg&w=3840&q=75)
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- The plasma profiles of codeine (COD) and metabolites for 2 individuals (labeled A and B) are shown below. The X-axis is time in hours after an oral dose of codeine. [M=morphine; C6G=COD-6-glucuronide; M3G = morphine-3-glucuronide; NM (ignore)]. Note the data is shown on a log scale on the Y-axis. (A) Which individual is the poor metabolizer? Explain how you know this from the profiles? (B) Is this a problem for cough suppression? Explain. -CH HO Codeine COD 10 000 1000 C6G COD 100 M3G M6G NM 10 M 10 20 30 0 10 20 30 Plasma concentration (nmol I-)One general guideline for the maintenance dosing of heparin in pediatric patients is 100 units/kg every4 hours, or 20,000 units/m²/24 hour administered continuously. The a vailable injection for use by intravenous infusion contains 1000 USP Heparin Units/mL For a 44-lb child, measuring 42 inches in height, calculate the difference between the quantities of heparin administered over a 24-hour period in (a) heparin units, (b) in milligrams of heparin (sod ium), and (c) in milliliters of heparin injection.Infuse dopamine 800 mg in 500 mL D5W at 30 mL/hr. Calculate the dosage in mcg/hr and mcg/min. Available: NDC 0143-9253-01 DOPamine Hydrochloride Injection, USP 400 mg/5 ml (80 mg/ml) 50 ONLY 1. Sipale Deco Mial a. mcg/hr 29 b. mcg/min 20 CAUTION: MUST BE DILUTED. FOR INTRAVENOUS USE. Each mL also contains sodium metabisulfite 9 mg added as stabilizer. Citric acid, anhydrous 10 mg and sodium citrate, dehydrate 5 mg added as buffer. Sterile, nonpyrogenic. WHOMA FARMACEUTICA PORTUGAL SA NDC 0143-9253-01 TEM CODE for-samith ama Lot: Exp: c. Calculate the number of milliliters you will add to the IV for this dosage. mL
- Mrs B presents you with a prescription for warfarin tablets 1 mg. The directions are to take 6 mg at 6pm that evening, followed by alternating daily doses of 4 mg and then 3 mg (as long as her INR remains within the recommended range). What is the exact number of warfarin 1 mg tablets required for a 28 day supply assuming her INR remains in range?IV D5W/NS with 20 mEq KCL 1,000 mL/8 hr Allopurinol 200 mg PO tid Fortaz 1 g IV q6h Aztreonam (Azactam) 2 g IV q12h Flagyl 500 mg IV q8h Acetaminophen two tablets q4h prn A.Calculate mL/hr to set the IV pump. B. Calculate how many tablets of allopurinol will be given PO. Supply: 100 mg/tablet. C. Calculate how many mL/hr to set the IV pump to infuse Fortaz. Supply: 1-g vial to be diluted 10 mL of sterile water and further diluted in 50 mL NS to infuse over 30 minutes. D. Calculate how many mL of aztreonam to draw from the vial. Supply: 2-g vial to be diluted with 10 mL of sterile water and further diluted in 100 mL NS to Infuse over 60 minutes. E. Calculate how many mL/hr to set the IV pump to infuse Flagyl. Supply: 500 mg/100 mL to infuse over 1 hour.A 30-year-old female patient with uncontrolled hypertension is suspected by an investi- gating endocrinologist of having Conn's syndrome. Results of routine biochemistry were (reference ranges are given in brackets): Sodium Potassium Urea Creatinine Alkaline phosphatase Alanine aminotransferase Albumin Bilirubin Calcium 146 mmol/L 2.1 mmol/L 7.2 mmol/L 146 μmol/L 290 IU/L 20 IU/L 49 g/L 8 μmol/L 2.19 mmol/L (135-145) (3.5-5.0) (3.5-6.6) (70-150) (95-320) (5-42) (35-50) (<17) (2.12-2.62) (a) Are any of the electrolyte concentrations abnormal, and if so what condition is suggested? (b) What further biochemistry investigations would you undertake? Explain your reasoning.
- Insulin Lispro subcutaneously for a patient weight 80 kg for 1 month of treatment. Daily dose of insulin is 1 Unit/kg and 60% in short acting, given 4 times per day; ampoules in form of personal injectors (300 Units/3ml). (I would like to figure out the number of personal injector needed for 1 month.) My answer: Daily dose (DD) for a 80 kg patient = 80 x 1 Unit = 80 U 60% is short acting, so DD = 60% of 80 U = (0.6 × 80) U = 48 U Given 4 times per day, so for a single dose = 48 U/4 = 12 U For 1 month (30 days), 30 x 48U = 1440 U Rp. Insulin lispro in ampoules personal injectors 300 Units/3 ml No. ??? (my teacher write is 10 but I don't understand why) Sig. Inject subcutaneously 12 Unit (0.12 ml) before each meal, 4 times a day for 1 month.The order in the MAR is for Atropine 15 mg IV q6h hours PRN. How many mL will you give if the dosage strength is 75mg/7.5mL?Jyan is 4 months pregnant and requires an IV infusion of magnesium sulfate heptahydrate at a rate of 8 g/hr for 5.6 hours. Magnesium Sulfate Concentrated Injection (2.465 g magnesium sulfate heptahydrate (MgSO4,7H2O MWt = 246.5) in each 5 mL ampoule) is to be diluted with 5% w/v glucose solution to a concentration of 20 %w/v for infusion. What volume of 5% w/v glucose solution is required? (Whole number answer.) Answer is 133 mL Note:please answer the question within two hours
- What is the approximate rate of change of A340 measured? i.e. ΔA340 / min = __________ What rate of change of A340 would you predict if 30 ml of the ADH solution was tested in the same way (i.e. half the amount of protein) ? i.e. ΔA340 / min = __________ What rate of change of A340 would you predict if 60 ml of a 0.5 μM ADH solution was tested in the same way? i.e. ΔA340 / min = __________ As well as writing your answers, explain your reasoning.Your 67 YO 195lb, 5ft 10in male patient diagnosed with testicular cancer has been prescribed ifosfamide 1200mg/M2/day IV for 5 days. You calculate the BSA using the mosteller method as being 2.09m2. Ifosfamide is available in 60mL vials contianing 3g of drug. a) How many mL will you administer each day?Jyan is 4 months pregnant and requires an IV infusion of magnesium sulfate heptahydrate at a rate of 5 g/hr for 5.3 hours. Magnesium Sulfate Concentrated Injection (2.465 g magnesium sulfate heptahydrate (MgSO4.7H₂O MWt = 246.5) in each 5 mL ampoule) is to be diluted with 5% w/v glucose solution to a concentration of 20 %w/v for infusion. What volume of 5% w/v glucose solution is required? (Whole number answer.)