All of the following statements about the B-oxidation pathway are true except: The pathway is suppressed by NADH and acetyl CoA. The committed step involves an acyl carrier protein (ACP). O In prokaryotes, the redox reactions occur in the cytoplasm. Each round shortens the fatty acid chain by two carbons.
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- Which of the following is true regarding the oxidation of 1 molecule of palmitate to 8 molecules of acetyl CoA by the beta-oxidation pathway? 7 molecules of FADH2 are formed None of the above 8 molecules of FADH2 are formed 8 molecules of NADH are formed BOTH 8 molecules of NADH are formed AND 8 molecules of FADH2 are formedWhich of the following is incorrect about the fifth step (conversion of succinyl-CoA, GDP, and Pi to succinate and GTP) of the citric acid cycle? a. GTP is made because succinyl-CoA is a thioester b. It is not regulated c. It involves a "substrate level" phosphorylation of GDP d. It is irreversibleWhat enzyme is inhibited by the group of medications known as statins? a)HMG-CoA synthase b)Aromatase c)Fatty acid synthase d)Cyclooxygenase
- Which of the following citric acid cycle enzymes catalyzes substrate-level phosphorylation? A) isocitrate dehydrogenase B) α-ketoglutarate dehydrogenase C) succinyl CoA synthetase D) succinate dehydrogenase E) malate dehydrogenaseWhich of the following is NOT produced during the reactions of acetyl-CoA formation? (only one choice is correct) A. Acetyl CoA B. Electrons C. CO2 D. ATPThe Krebs cycle reaction shown below is catalyzed by __ enzyme and ___ pays for this reaction note only major metabolites are shown a. Synthetase, hydrolysis of acetyl CoA b. Synthase, hydrolysis of acetyl CoA c. Synthase, hydrolysis of NADH d. Synthetase, hydrolysis of ATP
- In order to break the carbon-carbon bond of Acetyl-CoA in a way that does not harm the cell, citrate is produced in the TCA cycle. Explain how switching between 6-carbon, 5-carbon and 4-carbon metabolites eventually allows the two carbons of Acetyl-CoA to be converted to CO2 in a way that does not harm the cell.When one acetyl CoA is processed through the citric acid cycle, how many times does each of the following events occur? a. A FAD molecule is a reactant. b. A CoA-SH molecule is produced. c. A dehydrogenase enzyme is needed for the reaction to occur. d. A C5 molecule is produced.Which of the following statements are TRUE?Multiple answers are accepted for this question a .Two molecules of CO2 are produced each time a molecule of Acetyl-CoA is oxidized. b. During the first turn of the TCA Cycle the carbon atoms of Acetyl-CoA become CO2. c. The number of molecules of ATP that can be produced in the Citric Acid Cycle by substrate level phosphorylation of ADP from two molecules of Acetyl-CoA is 30. d. Fumarate contains a trans double bond. The cis isomer of Fumarate is Maleate which cannot serve as carbon source for a cell. e. Lack of O2 would decrease the rate of the Citric Acid Cycle in red blood cells. f. If a potent inhibitor of Succinyl-CoA Synthetaseis is applied to liver cells both energy production and synthesis of carbohydrate would be affected. g. The overall chemical changes that occur during one complete turn of the Citric Acid Cycle is the complete oxidation of one molecule of Acetyl-CoA plus the production of two molecules of CO2 plus the…
- Place the following list of reactions or relevant locations in the β oxidation of fatty acids in the proper order. (a) Reaction with carnitine (b) Fatty acid in the cytoplasm (c) Activation of fatty acid by joining to CoA (d) Hydration (e) NAD+ -linked oxidation (f) Thiolysis (g) Acyl CoA in mitochondrion (h) FAD-linked oxidation.Acetly CoA can quickly enter the citric acid cyle by joining with a C4 compound and forming citrate. Meanwhile, GTP (or ATP) is generated using inorganic phosphate while succinyl CoA is converted to succinate. What is the main reason both acetly CoA and succinyl CoA can perform such work? a. Acetyl CoA and succinyl CoA both contain coenzyme A, which is a high-energy compound. b. Acetyl CoA and succinyl CoA both form an unstable thioester bond with coenzyme A. c. Acetyl CoA and succinyl CoA both bind with inorganic phosphate which is used to generate ATP (or GTP). d. Acetyl CoA and succinyl CoA both transiently form a covalent bond with the enzymes that catalyze the next reaction, pyruvate dehydrogenase and succinyl-CoA synthetase, respectively. e. Acetyl CoA and succinyl CoA use the energy collected from the electron transport chain.Which of the following statements is/are TRUE about fatty acid activation before β-oxidation? I. The process consumes energy equivalent to two moles of ATP. II. The fatty acid is activated by ATP to give a fatty acyl-CoA.