Answered: A mutation of Lysine to Alanine in the…

A mutation of Lysine to Alanine in the middle of TM1 has been associated with increased GPCR instability in the lipid bilayer. Suggest a reason for the observation based on IMFs.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter32: The Reception And Transmission Of Extracellular Information

Section: Chapter Questions

Problem 11P

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Concept explainers

Osmosis

In simple words, osmosis is the slow, gradual movement of a liquid through a membrane. But there are nuances to this process. For instance, there has to be an imbalance in the distribution of solute in the liquid on either side of the membrane, which has to be semipermeable. The liquid in the region with a lower solute concentration moves to the region with a higher concentration, thereby displacing the solution in the process. The objective is to equalize the concentration of molecules on both sides of the membrane; the displacement of liquid can be viewed as a byproduct of this equalization. Since there is no energy required to carry osmosis, it is considered a passive process.

Question

A mutation of Lysine to Alanine in the middle of TM1 has been associated with increased GPCR instability in the lipid bilayer. Suggest a reason for the observation based on IMFs.

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Step 1: Introducing Lipid Bilayer

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Step 2: Explaining the relationship between mutation of lysine to alanine & increased GPCR instability.

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