36- . Proteins acting as a molecular switch fall mostly in two classes; and a) Nuclease - Ligases b) Ubiqutinase - Protein Kinase C) Methyl transferase - Protein Phosphates d) O Protein Kinase - Protein Phosphatase
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- 10. In eukaryotic cells, glycosylation activity of membrane proteins is found in the lumen of the endoplasmic reticulum (ER) and is accomplished by the enzyme oligosaccharyl transferase (OST), which adds oligosaccharides to the amino group of Asn residues of the consensus sequence Asn-X-Thr/Ser. a. The following ER membrane protein construct has a cytosolic N-terminal region and a membrane-spanning variable sequence. The variable sequence is a signal anchor (SA) sequence. Would you expect the C-terminal region of the B subunit to be glycosylated? Why or why not? variable sequence C-terminal region of B-subunit N-terminal region b. An additional transmembrane region is added to the construct prior to the variable sequence, as shown below. The transmembrane is a signal anchor (SA) sequence, while the variable sequence is a stop transfer anchor (STA) sequence. Would you expect the C-terminal region of the B subunit to be glycosylated? Why or why not? C-terminal region of B-subunit…Shown is part of the coding strand of the HBB gene involved in sickle cell disease. What will be the effect on the resulting peptide of a deletion of the two nucleotides shown in bold/underline? 5' CTG ACT CCT GAG GAC 3' a) A change from glutamic acid to valine will occur b) The deletion will not result in a change to the polypeptide c) A nonsense mutation will occur d) The polypeptide will be missing one amino acid, but the reading frame will be preservedIdentify the following mutations and describe what the possible effect on the protein will be. (4) 5’GAT TTT AGC TTA GCC CAT 3’ 5’ GAT TAG CTT AGC CCA T 3’ 3’CTA AAA TCG AAT CGG GTA 5’ 3’ CTA ATC GAA TCG GGT A 5’ 5’ GAT TTT AGC TTA CCC CAT 3’ 5’ GAT TTT AGC TAA CCC CAT 3’ 3’ CTA AAA TCG AAT GGG GTA 5’ 3’ CTA AAA TCG ATT GGG GTA 5’
- 4:32 120-201 FA22 Homework 02 2.docx 10. When a primary signal needs to be sent to most cells throughout a multicellular organism, the signal most suited for this is a AG) neurotransmitter. AH) hormone. AI) dissolved gas. AJ) transcription factor. AK) translation elongation factor Answer: Explanation: 5G 100 AM) the steroid hormones AN) tyrosine-derived epinephrin and norepinephrin AO) serotonin and melatonin (tryptophan-derived mammalian neurotransmitters) 11. Hydrophobic primary messengers usually cause molecular changes leading to modifications in metabolism. Examples of hydrophobic primary messengers are Explain what are their general chemical properties. AL) thyroxine (tyrosine-derived hormone) and insulin (a small peptide hormone) AP) auxins (tryptophan-derived plant hormones) Answer: Explanation: 12. Which statement regarding cell-surface receptors is correct? AQ) lon-channel-coupled receptors alter the membrane potential directly by changing the permeability of the plasma…One of the amino acid sequences in the lysozyme protein from the bacterial virus T4 studiesby Streisinger and co-worker was .... Lys – ser – pro – ser – leu – asn – ala – ala – lys. Thisparticular amino acid was found to have changed to lys – val – his –his –leu –met –ala –ala–lys... as a result of a single nucleotide deletion and addition approximately 15 bases apartin the mRNA. Which base was deleted and which was added? Give the altered sequence of bases inthe altered amino acid.Scientists IPed a mutant version of KDM3A with serine 264 altered to aspartic acid (dubbed S/D mutation). They IPed S/D in cells that had not been subjected to heat shock (HS-) or heat shock (HS+). 1) what is the purpose of mutating serine-264 to aspartic acid? 2) what conclusions can scientists make based on results of lane5 and lane 6?
- One of the amino acid sequences in the lysozyme protein from the bacterial virus T4 studiesby Streisinger and co-worker was .... Lys – ser – pro – ser – leu – asn – ala – ala – lys. Thisparticular amino acid was found to have changed to lys – val – his –his –leu –met –ala –ala–lys... as a result of a single nucleotide deletion and addition approximately 15 bases apartin the mRNA.a. What is the sequence of the nucleotides that produce the original protein.b. Which base was deleted and which was added? Give the altered sequence of bases inthe altered amino acid.21. Which protein structure is most consistent for the hydropathy graph of the intrinsic membrane protein shown below? +168 F +84 -84 -168 20 100 200 300 First amino acid in window A) A seven-helix serpentine receptor B) A Type I integral membrane protein C) A Type Il integral membrane protein D) A GPI-anchored protein E) A beta-barrel protein with about 10 membrane-spanning strands. Hydropathy index (kJ mol-1)8) A Leu > Ala mutation at a site buried in the core of the enzyme lysozyme ends up being destabilizing. Explain why in terms of AH", AS" (for both the protein and solvent), and AG".
- Each type of molecule listed below is recognized by a specific class of nuclear import receptor (importin) or nuclear export receptor (exportin). For each type of molecule, state whether you think it is recognized by an importin or exportin and explain why (in terms of where that molecule is synthesized, what that molecule does, and where it does it). (a) RNA polyermase II: (b) ribosomal protein: (iii) †RNA:Which of the following statements is true? Question 9 options: a) Executioner caspases are activated by cleavage. b) Initiator caspases are activated by cleavage. c) Executioner caspases are activated by dimerization. d) Executioner caspases trigger apoptosis but initiator caspases does not.You are studying a eukaryotic protein PKK in the lab. You fuse the DNA encoding GFP (green fluorescent protein) to the C terminus of the PKK gene. You also create the following GFP-PKK variants -GFP Wild- type: N- Signal sequence Transmembrane domain Kinase domain Variant 1: N- GFP Transmembrane domain Kinase domain Variant 2: N- -GFP Signal sequence Transmembrane domain Variant 3: N- -GFP Signal sequence Kinase domain Variant 4: N- -GFP Kinase domain If you examine wild-type PKK trafficking in a eukaryotic cell, which of the following are true? Select all that apply This fusion protein will be trafficked to the nucleus This fusion protein is a cell membrane protein This fusion protein will be trafficked to the Endoplasmic Reticulum This fusion protein is a nuclear protein