Shown is part of the coding strand of the HBB gene involved in sickle cell disease. What will be the effect on the resulting peptide of a deletion of the two nucleotides shown in bold/underline? 5' CTG ACT CCT GAG GAC 3' a) A change from glutamic acid to valine will occur b) The deletion will not result in a change to the polypeptide  c) A nonsense mutation will occur d) The polypeptide will be missing one amino acid, but the reading frame will be preserved

Biology (MindTap Course List)
11th Edition
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
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Chapter13: Gene Expression
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Problem 12TYU
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Shown is part of the coding strand of the HBB gene involved in sickle cell disease. What will be the effect on the resulting peptide of a deletion of the two nucleotides shown in bold/underline?

5' CTG ACT CCT GAG GAC 3'

a) A change from glutamic acid to valine will occur

b) The deletion will not result in a change to the polypeptide 

c) A nonsense mutation will occur

d) The polypeptide will be missing one amino acid, but the reading frame will be preserved

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