Column A Column B a. NOD2 1. carbohydrate b. TLR4 2. muramyl dipeptide c. dectin-1 3. Y-glutamyl diaminopimelic acid d. CR3/CR4 4. teichoic acid e. NOD1 5. lipopolysaccharide (LPS) f. SR-A 6. filamentous hemagglutinin g. TLR9 7. unmethylated CpG-rich nucleotide motif
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Match the receptor in column A with its ligand in column B.
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- Make an illustration that connects the events in inflammation mediated by chemical substances. Use the following words to come up with the output connected by arrows. 1. Modified proteins 16. C142356789 2. Kininogen 3. Prostaglandins 4. Clotting system 5. Antigen 17. Kallikrein 18. Platelets 19. Serotonin 20. Kinins 21. C1423 22. Anaphylotoxins 6. Lysosomal enzymes 7. Antibody 8. C1 9. Kallikreinogen 23. Chemotactic factor 24. Serum factors 10. C142 25. C14235 11. Antigen/Antibody 12. Cells migration 26. C1423567 27. Injurious stimuli 13. Histamine 28. Acute inflammation 14. Plasmin system 29. Increased vascular permeability 15. C3 30. Chronic inflammationDescribe in detail the effect of loss or mutation of LAT & Blk of the following molecules/proteins/genes/domains in immune signaling. Be sure to include the normal function and the function effected by the mutation. Include all relevant players and their roles. You may use diagrams if needed.Which of the following are true of interferons? Select all that apply. O They are a critical part of the innate immune system in fighting bacterial infections O They are a part of the second line of defense against viruses O They degrade viral DNA O They are signaling molecules produced by infected cells to help uninfected cells defend themselves agains viruses O They are part of innate immunity O They are part of adaptive immunity and are "trained" by the immune system to eliminate specific pathogens
- Which of the following apply to the specific function of IL-2? OIL-2 promotes vasodilation and vascular permeability OIL-2 promotes rapid mitosis by lymphocytes IL-2 promotes the perforation of the plasma membrane of host cells infected with an intracellular pathogen O None of the statements apply OIL-2 promotes complement-directed lysis of the pathogen OIL-2 promotes fever. What signaling molecules do macrophages secrete? Interferon Interleukin-1 Histamine Only a and bSerum from individuals with high levels of antibody to SARS-CoV2 has been used to treat patients with severe COVID-19. What is ONE way (there are several) that passive immunization with the antibody to the virus could help these patients? HINT: think about what opsonization with antibody could do for the innate immune response.
- %VY lI, نقطة واحدة Q/ finger-like projections that arise from the epithelial layer in some organs are called Cilia Villi Microvilli Non of the above ösly äbäi Q/ The cell of connective tissue that contain serotonin to immediate * hypersensitivity is Histiocyte cell Mast cell Adipose cell Fibroblast cell هذا السؤال مطلوب صفحة 2 من 3 التالي II >Describe in chronological order the steps involved in the recruitment of neutrophils to infected tissue sites during an innate immune response. Use the following terms in your description: rolling adhesion, tight binding, extravasation, migration, inflammatory mediators, integrins, adhesion molecules, chemokines, selectins, sialyl-Lewisx, and basement membrane proteases.Describe the signal transduction pathway that is activated when LPS binds to TLR-4.
- Complement can enhance phadocytosis because of the presence on macrophages and neutrophils of receptors for: а. Factor D b. C3b c. C6 d. C9Gram negative cell walls contain lipopolysaccharide (LPS) as a unique component. All of the following apply to LPS EXCEPT O LPS is composed of mycolic acids that protect the cell from phagocytosis LPS is a PAMP that can be recognized by toll-like receptors (TLRS) as a foreign molecule fo rphagocytosis O LPS can be a target for specific IgG for ADCC-opsonization LPS can be recognized by B cells in the aosence of MHC molecules All of the answers apply, no exception O LPS is found in the outer membrane of Gram negative cellsToll-like receptors represent an ancient pathogen-recognition system. The first pattern recognition receptor (PRR) important in innate immune responses was discovered in the fruit fly Drosophila melanogaster. Stimulation of this receptor, called Toll, induces: The synthesis of prostaglandins and leukotrienes The inflammatory response in Drosophila hemolymph vessels The production of antimicrobial peptides The recruitment of phagocytic cells to the site of infection The activation of Drosophila complement