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3. Read the article "An update of the chemiosmotic theory as suggested by possible proton currents inside the coupling membrane." and address the following questions. (one paragraph each) a) How does the Grotthuss mechanism and proton translocation through the membranes differ from the notion that protons are "pumped" from one side of the membrane to another? b) Focusing on the mechanism linking complex I and ATP synthase depicted in figure 3 in the article, compare that hypothetical mechanism to the classical presentation described in our textbook (refer to the diagram in your Answer). What are the major differences between this mechanism and Peter Mitchel's original chemiosmotic theory? What are the similarities. c) The authors bring up arguments for why the proton Mitchel's proton gradient mechanism is implausible. What is the most important of these and what is the compelling evidence to support these authors proposal that some of the tenets of chemiosmotic theory need revision.

3. Read the article "An update of the chemiosmotic theory as suggested by possible proton currents inside the coupling membrane." and address the following questions. (one paragraph each) a) How does the Grotthuss mechanism and proton translocation through the membranes differ from the notion that protons are "pumped" from one side of the membrane to another? b) Focusing on the mechanism linking complex I and ATP synthase depicted in figure 3 in the article, compare that hypothetical mechanism to the classical presentation described in our textbook (refer to the diagram in your Answer). What are the major differences between this mechanism and Peter Mitchel's original chemiosmotic theory? What are the similarities. c) The authors bring up arguments for why the proton Mitchel's proton gradient mechanism is implausible. What is the most important of these and what is the compelling evidence to support these authors proposal that some of the tenets of chemiosmotic theory need revision.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Article - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501646/

Here are the articles provided within the question - They are not needed but are available if additional information is warranted - The figures being mentioned are already provided. This is Biochemoistry, please answer each part to the best of your ability. There are a max of 3 parts due to guidelines and please answer each part with clear and efficient work with answers. Thank you

matrix side or n side NADH + H+ NAD+ complex I ADP + P; 1 a subunit booooood putative proton current by Brownian motion INS sepéééééé F1 ATP synthase ОН ОН ОН ОН Ó <d d OH OH HOFO ATP synthase HO OH OH OH OH OH putative proton tunnelling through a subunit ATP glutamic 58 of c subunit periplsmatic side or p side Figure 3. A possible H+ circuit inside respiring membrane. The phosphate groups of phospholipids on both sides of the membrane are shown by brown ellipsoids. The image proposes that the H+ (red dotted line) are transferred to the Glu 58 (E58) at the centre of subunit c through subunit a of ATP synthase by proton tunnelling. H+ would flow from the periplasmic side, always bound to phospholipid heads. This can be arranged in each layer of the membrane.
Transcribed Image Text:matrix side or n side NADH + H+ NAD+ complex I ADP + P; 1 a subunit booooood putative proton current by Brownian motion INS sepéééééé F1 ATP synthase ОН ОН ОН ОН Ó <d d OH OH HOFO ATP synthase HO OH OH OH OH OH putative proton tunnelling through a subunit ATP glutamic 58 of c subunit periplsmatic side or p side Figure 3. A possible H+ circuit inside respiring membrane. The phosphate groups of phospholipids on both sides of the membrane are shown by brown ellipsoids. The image proposes that the H+ (red dotted line) are transferred to the Glu 58 (E58) at the centre of subunit c through subunit a of ATP synthase by proton tunnelling. H+ would flow from the periplasmic side, always bound to phospholipid heads. This can be arranged in each layer of the membrane.
3. Read the article "An update of the chemiosmotic theory as suggested by possible proton currents inside the coupling membrane." and address the following questions. (one paragraph each) a) How does the Grotthuss mechanism and proton translocation through the membranes differ from the notion that protons are "pumped" from one side of the membrane to another? b) Focusing on the mechanism linking complex I and ATP synthase depicted in figure 3 in the article, compare that hypothetical mechanism to the classical presentation described in our textbook (refer to the diagram in your Answer). What are the major differences between this mechanism and Peter Mitchel's original chemiosmotic theory? What are the similarities. c) The authors bring up arguments for why the proton Mitchel's proton gradient mechanism is implausible. What is the most important of these and what is the compelling evidence to support these authors proposal that some of the tenets of chemiosmotic theory need revision.
Transcribed Image Text:3. Read the article "An update of the chemiosmotic theory as suggested by possible proton currents inside the coupling membrane." and address the following questions. (one paragraph each) a) How does the Grotthuss mechanism and proton translocation through the membranes differ from the notion that protons are "pumped" from one side of the membrane to another? b) Focusing on the mechanism linking complex I and ATP synthase depicted in figure 3 in the article, compare that hypothetical mechanism to the classical presentation described in our textbook (refer to the diagram in your Answer). What are the major differences between this mechanism and Peter Mitchel's original chemiosmotic theory? What are the similarities. c) The authors bring up arguments for why the proton Mitchel's proton gradient mechanism is implausible. What is the most important of these and what is the compelling evidence to support these authors proposal that some of the tenets of chemiosmotic theory need revision.
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