What is the concentration of B expressed in terms of A if the Kd is 33.0 uM, and the concentration of AB is 56.0 uM? A + B <=> AB OB= 1850/A OB= 23-A OB=23+ A OB= 0.589/A
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- Calculate the creatinine clearance for Lola, a 69 year old woman who weighs 66kg and has a serum creatinine of 125micromoles/L. Round your answer to 2 decimal places Cockroft Gault equation: [ X (140-age) x (weight in kg)] / serum creatinine (in micromole/L) Where X = 1.04 for females and X = 1.23 for malesFigure 5 shows oxyhemoglobin dissociatlon curves at pH 7.2 and pH 7.4. Which of the following is true at PO2 less than 40 mm Hg? 27. % saturation af haemogiobin 100 pH 7.4 80 60 pH 7.2 40 + 20 10 20 30 40 50 60 70 Po; (mm Hg) Figure 5 A. Hemoglobin retains less O2 at pH 7.4 compared to pH 7.2. B. Hemoglobin retains less O2 at pH 7.2 compared to pH 7.4. C. The release of O2 from hemoglobin is not influenced by the production of CO2. D. At pH 7.2 where CO2 production is less than pH 7.4, hemoglobin releases less O2.Below is the O2 binding curve for adult Hb in whole blood (containing BPG) shown in red (labelled Hb). A Hb 20 40 60 80 100 pO2 (torr) a. Which curve is the best representation for stripped Hb (pure hemoglobin with heme, but no other small allosteric molecules associated)? [ Select ] b. Which curve has the lowest affinity (as measured by the p5o)? [ Select ] c. Which curve lacks cooperativity? [ Select ] Fraction of Hb bound with Oxygen 0.2 0.4 0.6 0.8 0'0 >
- Draw a standard curve (using linear graph paper) of A595 (Y axis) versus μg protein for tubes 1-6 (standards) and use this to determine the amount of protein in each of the fractions (serum, B and crude IgG). Calculate the total amount of protein in the starting serum and the amount recovered in each of fraction B and the IgG fraction (you need to know the total volumes of these samples). The volume recorded for fraction c was 1ml and fraction b was 11ml. Please I need helpHemoglobin poz in lungs tissues (4,500 m) po2 in lungs (sea level) po2 in 8. Lack of 2,3-BPG can be deadly. 1.0 BPG = 0 mM 38% A) What is 2,3-BPG? How is it produced and why does hemoglobin need 2,3- 30% ВPG? 37%- Y 0.5 B) Under what physiological conditions are blood levels of 2,3-BPG elevated? C) How does an increased level of 2,3-BPG help our bodies compensate through crises of a low availability of external oxygen? Highlight the action of 2,3-BPG on hemoglobin in your answer. BPG - 5 mM at sea level BPG 8 mM at high altitudes (4,500 m) 4 8 12 16 pO2 (kPa) Figure 5-17 Lehninger Principles of Biochemistry, Seventh Edition O 2017 W. H. Freeman and CompanyA child weighing 22 lbs, has an infection and the doctor orders erythromycin drops 2.0 mLp.o. q6h. The bottle states that the usual dosage is 20.0-40.0 mg/kg/day, and there are35.0 mg per 1.5 mL. Find the min and max dosage per day in mL. Is the order within therecommended dosage?
- KCI for injection contains 40 mEq in 20 mL. An order requires 15 mEq, how many mL are needed?A 72-year-old adult patient who weighs 78 kg is prescribed by the doctor “Potassium Chloride 40meq in 1L to run for 8 hours” via the peripheral line for a potassium level of 3.3 mEq/L that was drawn this morning. Note: 10 mEq of potassium chloride increases serum potassium levels by approximately 0.1 mEq/.L The concentration of potassium for intravenous administration via a peripheral line should not exceed 40mmol / 500 mL 10 mEq/hr maximum infusion rate; not to exceed 200 mEq dose/24hr Administration rates above 20mmol/hour require cardiac monitoring. How much will the order medication “Potassium Chloride 40meq in 1L to run for 8 hours” raise the patient's potassium level in a day? Is it still within the normal potassium serum levels, which is 3.5–5.0 mEq/L? Does the order comply with the maximum concentration of potassium to be administered peripherally? Does the order’s infusion rate do not exceed the standard maximum infusion rate? Does the order require cardiac monitoring?From the following data, find the % (w/w) cream of tartar (KHC4H406, MM=188): Wt of sample = 1.4160 g NaOH titrant used = 20.87 mL HCI used for back titration = 1.27 mL 1.00 mL HCI 1.12 mL NaOH 1.00 mL HCI A 0.01930 g CaCO3 89.08% (w/w) 87.12% (w/w) O 47.75% (w/w) O 95.59% (W/w)
- Colin who is 78 years old has been admitted to a ward where you are working, with acute bacterial meningitis. The duty doctor wants to treat with meropenem and she would like to know what dose to treat with. In Colin’s notes you see that he has a history of kidney injury, you have his weight which is 49kg and his serum creatinine is 157micromol/L. What is Colin’s estimated creatinine clearance? 2. What is the maximum daily dose (in grams) of meropenem that Colin will receive?A cat presents with suspected acute, severe sepsis. The veterinarian asks you to draw up a dose of IV gentamicin. The dosage for a cat with acute sepsis is 2.2 mg/kg. Calculate the dose for an 8-lb cat. The concentration of gentamicin is 50 mg/ml. Show me your calculation Please note that: 1Kg= 2.2 lbColin who is 78 years old has been admitted to a ward where you are working, with acute bacterial meningitis. The duty doctor wants to treat with meropenem and she would like to know what dose to treat with. In Colin’s notes you see that he has a history of kidney injury, you have his weight which is 49kg and his serum creatinine is 157micromol/L. What is Colin’s estimated creatinine clearance? X([140-age] × weight in kg)/(serum creatinine IN micromol/L Where X =1.04 for female and X= 1.23 for male 2. What is the maximum daily dose (in grams) of meropenem that Colin will receive?
