21. The melting points (mp) of three beta agonist homologues are given below OH HO. ОН Terbutaline mp 119-122°C HO. OH HY OH

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21. The melting points (mp) of three beta agonist homologues are given below
OH
HO
OH
Terbutaline mp 119-122°C
OH
zey
HO.
OH
Metaproterenol mp 100°C
НО.
HO
OH H
N
Isoproterenol mp 155.5°C
What is their expected order of solubility in water, from lowest to
highest?
A. Terbutaline>metaproterenol>isoproterenol
B. Metaproterenol>terbutaline>isoproterenol
C. Isoproterenol>metaproterenol>terbutaline
D. Isoproterenol>terbutaline>metaproterenol
E. Metaproterenol>isoproterenol>terbutaline
26. The melting point of isosorbide-2,5-diaspirinate is higher than that of
aspirin. What is the significance of higher melting point in preformulation?
A. High melting point is generally associated with low aqueous solubility
B. High melting point is generally associated with high aqueous solubility
C. Melting point is inversely proportional to density
D. Melting point is used in the calculation of viscosity
E. A high melting point indicates better chemical and physical stability in
aqueous solution
Transcribed Image Text:21. The melting points (mp) of three beta agonist homologues are given below OH HO OH Terbutaline mp 119-122°C OH zey HO. OH Metaproterenol mp 100°C НО. HO OH H N Isoproterenol mp 155.5°C What is their expected order of solubility in water, from lowest to highest? A. Terbutaline>metaproterenol>isoproterenol B. Metaproterenol>terbutaline>isoproterenol C. Isoproterenol>metaproterenol>terbutaline D. Isoproterenol>terbutaline>metaproterenol E. Metaproterenol>isoproterenol>terbutaline 26. The melting point of isosorbide-2,5-diaspirinate is higher than that of aspirin. What is the significance of higher melting point in preformulation? A. High melting point is generally associated with low aqueous solubility B. High melting point is generally associated with high aqueous solubility C. Melting point is inversely proportional to density D. Melting point is used in the calculation of viscosity E. A high melting point indicates better chemical and physical stability in aqueous solution
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