The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

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Chapter 44, Problem 4A

Summary Introduction

Introduction:

The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

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Coat color in mammals is controlled by a hormone receptor called the melanocortin receptor. When this receptor is bound by the hormone MSH, pigment cells produce dark eumelanin. When the receptor is bound by an MSH antagonist that prevents MSH binding, pigment cells make yellow/red pheomelanin. In the Irish Setter, the overall red coat color could be due to a mutation in the a. receptor that prevents the antagonist from binding. b. receptor that prevents MSH from binding. c. MSH protein such that it binds the receptor more efficiently. d. antagonist such that it no longer binds to the receptor.

Thyroid hormone receptor (TR) regulates growth, development, and differentiation of mammals. TR contains both a domain that binds to T3, the thyroid hormone, and a separate domain that binds to DNA. Which of the following BEST explains how TR signals? A. T3 binds to TR at the cell membrane, which then releases second messengers to regulate gene expression. B. T3 binds to DNA at the cell membrane, which then releases second messengers to regulate gene expression. C. T3 diffuses through the cell membrane to bind to TR, which then binds to DNA to regulate gene expression. D. T3 diffuses through the cell membrane to bind to DNA, which then binds to TR to regulate gene expression.

In relation to Cushing’s Syndrome, a method that some scientists have used to treat the disease is to use small molecules that bind to, but do not activate, MC2R. This type of molecule is considered an antagonist. How can an antagonist bind to the same receptor as ACTH but not activate it ? a. The antagonist binds covalently while ACTH binds non covalently b. The antagonist is only partially complimentary to the binding pocket of MC2R c. The antagonist binds to ACTH and blocks it from binding to the receptor properly d. The antagonist is the exact same structure as ACTH but since it is synthetic it doesn’t work

Answer 2

Question

Chapter 44, Problem 4A

Summary Introduction

Introduction:

The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

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Answer 3

Question

Chapter 44, Problem 4A

Summary Introduction

Introduction:

The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

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Answer 4

Question

Chapter 44, Problem 4A

Summary Introduction

Introduction:

The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

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Answer 5

Chapter 44, Problem 4A

Summary Introduction

Introduction:

The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

Answer 6

Chapter 44, Problem 4A

Summary Introduction

Introduction:

The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

Answer 7

Chapter 44, Problem 4A

Summary Introduction

Introduction:

The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

Answer 8

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Answer 11

Ch. 44.1 - Prob. 1LO Ch. 44.1 - Prob. 2LO Ch. 44.1 - Prob. 3LO Ch. 44.2 - Prob. 1LO Ch. 44.2 - Prob. 2LO Ch. 44.2 - Prob. 3LO Ch. 44.3 - Prob. 1LO Ch. 44.3 - Describe the connections between the hypothalamus,...Ch. 44.3 - Prob. 3LO Ch. 44.4 - Prob. 1LO

The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

Solution Summary: The author explains that the mutation in the receptor will only allow MSH antagonist to bind with it and only red color coats will be produced.

Concept explainers

Introduction:

The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

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Chapter 44 Solutions

The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

Solution Summary: The author explains that the mutation in the receptor will only allow MSH antagonist to bind with it and only red color coats will be produced.

Concept explainers

Introduction: The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.

Want to see the full answer?

Chapter 44 Solutions

Introduction:

The hormones bind to their specific receptors in order to perform their functions. The binding of hormone-receptor may be altered by the presence of an antagonist, which binds to the receptor and blocks the activity of the hormone.