Explanation Given information: The statement “If the slope of the dose/response curve is large, a small change in the dose will have a large effect on the response”. A dose-response curve plots the intensity of physiological response to a drug as a function of the dose administered. As the dose increases, the intensity of the response increases, so a dose-response function is increasing. The intensity of the response is generally scaled as a percentage of the maximum response. The curve cannot go above the maximum response (or 100%), so the curve levels off at a horizontal asymptote. Dose-response curves are generally concave up for low doses and concave down for high doses. A dose-response curve can be modeled by a logistic function with the independent variable being the dose of the drug, not time. A dose-response curve shows the amount of drug needed to produce the desired effect, as well as the maximum effect attainable and the dose required to obtain it...

6th Edition

ISBN: 9781119399353

Author: DA

Publisher: JOHN WILEY+SONS,INC.-CONSIGNMENT

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Chapter 4, Problem 66SYU

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Whether the statement is true or false.

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Chapter 4, Problem 65SYU

Chapter 4, Problem 67SYU

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Step 2 of 2: Is there evidence of a linear relationship between the actual number of inhabitants and the estimated number? Test at the 0.010.01 level.

Sheila's doctor is concerned that she may suffer from gestational diabetes (high blood glucose levels during pregnancy). There is variation both in the actual glucose level and in the blood test that measures the level. A patient is classified as having gestational diabetes if the glucose level is above 140 miligrams per deciliter (mg/dl) one hour after having a sugary drink. Sheila's measured glucose level one hour after the sugary drink varies according to the Normal distribution with μμ = 120 mg/dl and σσ = 10 mg/dl. (a) If a single glucose measurement is made, what is the probability that Sheila is diagnosed as having gestational diabetes?(b) If measurements are made on 5 separate days and the mean result is compared with the criterion 140 mg/dl, what is the probability that Sheila is diagnosed as having gestational diabetes?

Shelia’s doctor is concerned that she may suffer from gestational diabetes (high blood glucose levels during pregnancy). There is variation both in the actual glucose level and in the blood test that measures the level. A patient is classified as having gestational diabetes if her glucose level is above 136 milligrams per deciliter (mg/dl) one hour after ingesting a sugary drink. Shelia’s measured glucose level one hour after the sugary drink varies according to the Normal distribution with μ = 125 mg/dl and σ = 11 mg/dl. a)What are the mean and standard deviation of the distribution of sample proportion if measurements are made instead on 40 separate days? b)If measurements are made on 40 separate days and the mean result is compared with the criterion 140 mg/dl, what is the probability that Shelia is diagnosed as having gestational diabetes? c)Let’s consider what could happen if we took 40 separate measurements from Shelia. What is the blood glucose level L such that the probability…

Chapter 4 Solutions

EBK APPLIED CALCULUS, ENHANCED ETEXT

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To indicate: Whether the statement is true or false.

Solution Summary: The author explains how the dose-response curve plots the intensity of physiological response to a drug. The slope of the curve gives information about the therapeutic safety margin.