Concept explainers
Interpretation:
The structure of a DNA-Bound bZIP transcription factor should be explained.
Concept introduction:
The structure is determined by five transcription factors. Each transcription factor is a member of special structural category. Representation of novel and unlooked-for DNA-binding motifs is done by TFIID TATA-binding super molecule. Determination of the structure of -bound super molecule is done by the exception of TFIID.Acknowledgement of specific
Answer to Problem 18P
C/EBP
Separating the sequence of the macromolecule before every essential amino acid residue gives:
Rearranging the sequence to allow 2 additional seven residue sequence gives:
Explanation of Solution
An essential amino acid zipper can also be represented in coiled-coil domain. It contains
C/EBP
Separating the sequence of the macromolecule before every essential amino acid residue gives:
This is often followed by a two residue repeats and 2 additional seven residue repeats. These 2 seven residue repetition begin the twenty eight residue essential amino acid zipper. Rearranging the sequence to allow 2 additional seven residue sequence gives:
The essential amino acid residues of the essential amino acid zipper are residues 48, 55, 62, and 69. Essential amino acid residue 76 might also participate within the essential amino acid zipper. All of those residues are on the C-terminal aspect of the chain along with the essential amino acid zipper.
An essential amino acid zipper could be a coiled-coil domain. Coiled-coil domains repeat each seven residues, thus we tend to expect one domain of the 1GU4 -helices to possess essential amino acid residues repetition each seven residues. Essential amino acid zipper domain contains 28 amino acids, thus we can expect four such repeats. The first essential amino acid repeat could be a seven residue repeat.
This is often followed by a two residue repeat and 2 additional seven residue repeats.
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Chapter 29 Solutions
BIOCHEMISTRY (HARDBACK) W/ACCESS CODE
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- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning