Concepts of Genetics (12th Edition)
Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 26, Problem 31ESP

Recent reconstructions of evolutionary history are often dependent on assigning divergence in terms of changes in amino acid or nucleotide sequences. For example, a comparison of cytochrome c shows 10 amino acid differences between humans and dogs, 24 differences between humans and moths, and 38 differences between humans and yeast. Such data provide no information as to the absolute times of divergence for humans, dogs, moths, and yeast. How might one calibrate the molecular clock to an absolute time clock? What problems might one encounter in such a calibration?

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Recent reconstructions of evolutionary history are often dependenton assigning divergence in terms of changes in amino acid ornucleotide sequences. For example, a comparison of cytochromec shows 10 amino acid differences between humans and dogs,24 differences between humans and moths, and 38 differencesbetween humans and yeast. Such data provide no information asto the absolute times of divergence for humans, dogs, moths, andyeast. How might one calibrate the molecular clock to an absolutetime clock? What problems might one encounter in such acalibration?
The second step to calculate the evolutionary rate is based on the values of p obtained above. The relationship between the evolutionary rate, 1 (i.e., changes in sequence per number of years), the proportion of different sites, p, and divergence time in years between the two species, t, is approximately: 21t=p 6. We are assuming that the average value of l applies to all lineages and that each pair of species shares a common ancestor. Given that, why does the formula have a factor of 2 on the left hand side? Hint: think about what happens at a divergence.
Crickets have colonized each island in the Hawaiian Archipelago. Geological data indicates that Kauai is the oldest island in the chain and Hawaii is the youngest. Researchers hypothesized that crickets sequentially colonized islands as they rose out of the ocean and created a cladogram based on molecular relationships to test this idea.  1) Mark & label (as “MRCA”) the most recent common ancestor for all crickets on the island of Kauai. 2) Molokai is roughly equally distant from Oahu as Maui, but not equally related. Are Molokai crickets more closely related to those on Oahu or Maui?_________

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Concepts of Genetics (12th Edition)

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