Molecular Biology of the Cell (Sixth Edition)
6th Edition
ISBN: 9780815344322
Author: Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher: W. W. Norton & Company
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Chapter 24, Problem 2P
Summary Introduction
To examine: Whether the statement “To guarantee that the antigen-presenting cells in the thymus will display a complete repertoire of self peptides to allow elimination of self-reactive T cells, the thymus recruits dendritic cells from all over the body” is true or false.
Concept introduction: Dendritic are antigen-presenting cells which are part of the adaptive immune response and are present in tissues which are in direct exposure to external environment. Once the dendritic cells are activated they interact with the T and B cells and express a wide variety of pathogen recognition receptors. The thymus is the site of production of the antigen-presenting cells like the dendritic cells.
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