Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 18.4, Problem 1R
Summary Introduction
To review:
The method, by which the small interfering ribonucleic acid (siRNA) could be used in treating bladder cancer, and whether the drug developed by this technology would be specific for the cancer or not.
Introduction:
The siRNA is small interfering ribonucleic acid (RNA). It was first discovered in 1990s. It is used in translation of messenger RNA (mRNA). It binds on the complementary region on the mRNA that is targeted for translation and then degrades the mRNA.
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Life: The Science of Biology
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- Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor biology, what is the mutator phenotype hypothesis? What are some ways in which error-prone polymerases could be targeted for potential anti-cancer treatments?arrow_forward1). Tumor suppressor proteins monitor DNA and detect damage. Some cancers evade this detection by removing tumor suppressor proteins from the nucleus. An overproduction of what transport molecule could cause this? What is one example of how this overproduction might be targeted for cancer treatment (suggest a hypothetical treatment that would prevent the cancer)? 2) :) Based on the course content thus far, would mRNA vaccines pose a risk to the genomic DNA in a cell? Explain.arrow_forwardSeveral research studies are under way that involve the use of genetherapies to inhibit the growth of cancer cells. Oncogenes are mutant genes that are overexpressed and cause cancer. New gene therapies are aimed at silencing oncogenes by producing antisense RNA that recognizes the mRNAtranscribed from oncogenes. Based on your understanding of antisense RNA , explain how this strategy would prevent the growth of cancer cells.arrow_forward
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