Chapter 16, Problem 4CT

Summary Introduction

To describe:

The immunological impairements that would result in mice deficient in each of the following $\text{class-I MHC}$, $\text{class-II MHC}$, $\text{TCR,BCR}$, $\text{Il-2receptor and IFN-γ}$.

Introduction:

Immune system activation causes the priming of $\text{BCR and TCR}$ with binding of the epitopic antigen inside the cleft of the receptor along with the major histocompability complex formation. It is formed on the surface of antigen presenting infected cells. $\text{B-cells and T-cells}$ release cytokines and interferon’s which cause apoptosis of the infected cells in the human body.