With the aid of a hand drawn diagram, briefly explain how T cells are primed or activated by B cells. In your response, briefly outline the major differences between B and T cell activation
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With the aid of a hand drawn diagram, briefly explain how T cells are primed or activated by B cells. In your response, briefly outline the major differences between B and T cell activation
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- It is often helpful to draw a complicated pathway in the form of a flow chart to visualize the multiple steps and the ways in which the steps are connected to each other. Draw the antibody-mediated immune response pathway that acts in response to an invading virus.The Adaptive Immune Response Is a Specific Defense Against Infection Name the class of molecules that includes antibodies, and name the five groups that make up this class.Figure 42.11 Which of the following statements about T cells is false? Helper T cells release cytokines while cytotoxic T cells kill the infected cell. Helper T cells are CD4+, while cytotoxic T cells are CD8+. MHC II is a receptor found on most body cells, while MHC I is a receptor found on immune cells only. The T cell receptor is found on both CD4+ and CD8+ T cells.
- Compare and contrast CD4 and CD8 T cells. Include in your response references to structure, activation, and effector function.Describe in detail what is meant by a "self- restricted/ self-tolerant" T cell. A diagram is helpful here.How could you distinguish the type of T cell that is active in an immune response? What outcomes would you be looking for to help determine which T cell is producing that result? Explain and provide examples.
- Describes the relationship of the following terms using short terms: Adhesion Molecule(s)Anergic T cellAntigen PresentationAntigen ProcessingHelper T cells can be activated by macrophages(which engulf everything indiscriminately) or by B cells (which only engulf antigens that stick to their receptors). A. What properties so macrophages and B cells have ibn common that allows them both to activate T cells? B. It has been suggested that macrophages probably do most to fhte T cell activating in the primary response but B cells do most of it in the secondary response. Why does this make sense?A mouse is infected with staphylococcal bacteria through a laceration in the skin of its paw. Dendritic cells are isolated from the tissue at the site of infection, and are incubated together with naïve staphylococcal-specific CD4 T cells. Seventy-two hours later, the proliferation of the CD4 T cells is measured as a readout for T cell activation. Surprisingly, the T cell response is quite poor compared to the response observed when the same T cells are mixed with a comparable number of dendritic cells isolated from the draining lymph node of the infected mouse. A comparison of the dendritic cells isolated from the two different sites would reveal: Much higher levels of MHC and B7 molecules on the lymph node dendritic cells than those from the infected tissue Much higher expression of all TLRs in the lymph node dendritic cells than those from the infected tissue An increased number of MHC class II molecules bearing bacterial peptides on the surface of dendritic cells from the infected…
- What occurs in a cell-mediated immune response? Select all that apply. Naive B cells bind to antigen on the surface of a bacterium and become activated. A dendritic cell incorporates digested viral antigen-MHC complexes. Naive cytotoxic T cells bind to antigen on antigen-presenting dendritic cells and become activated. Effector cytotoxic T cells circulate through the body and kill any body cells that display the viral antigen-MHC complexes.The diagram shows a pathogen (in red) that is present in different cellular compartments of each of the cell types shown. In each case, a specific T cell subset will recognize peptides of that pathogen presented on MHC molecules on the surface of the cell, and will execute its effector function. From the list below, match the appropriate T cell effector response to the cell type and location of the pathogen. CD4 T cell killing of target cell CD8 T cell killing of target cell CD4 T cell activation of target cell’s antibody production CD8 T cell activation of target cell’s antibody production CD4 T cell activation of target cell’s ability to kill intracellular pathogen CD8 T cell activation of target cell’s ability to kill intracellular pathogenT cells have to work in a partnership with an Antigen Presenting Cell (APC). Before this can occur, the APC must modify the antigen. Please discuss how this process happens and the major protein that is involved. Be detailed.
