Which statement describes a limitation of T-cell receptors (TCRs) compared to B-cell receptors (BCRs)? only BCRs recognize pathogen epitopes only BCRs can initiate a pathogen-specific immune response only BCRs can interact with epitopes on free antigens or epitopes displayed directly on the pathogen

Which statement describes a limitation of T-cell receptors (TCRs) compared to B-cell receptors (BCRs)? only BCRs recognize pathogen epitopes only BCRs can initiate a pathogen-specific immune response only BCRs can interact with epitopes on free antigens or epitopes displayed directly on the pathogen

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter12: Body Defenses

Section: Chapter Questions

Problem 14RE

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The innate immune response together with antibodies are generally not effective at clearing infections established by pathogens that replicate inside host cells. The evolution of T cells has provided a means for the immune response to ‘see’ intracellular infections based on the ability of T cells to: Secrete cytokines that diffuse into the infected tissue Activate type I interferon production by macrophages and dendritic cells Activate macrophages to induce inflammation Recognize pathogen-derived peptides on host MHC surface molecules Express cytoplasmic sensors for detecting pathogen-derived nucleic acids
Which of the following is TRUE regarding Gram negative bacteria? a- Their cell wall is composed of a large proportion of sugars b- Their cell wall does not absorb the Gram stain and turns pink c- Their cell wall is composed of a small proportion of peptidoglycan d- Two of the above statements are true Which T-lymphocytes activate the B-cell response? 1- suppressor T-cells. 2- cytotoxic T-cells. 3- helper T-cells. 4- memory T-cells. Substances that are injected containing an antigen to stimulate the immune system to respond are called a- antibodies b- medications. c- vaccines d- antibiotics
Which of the following is true about innate immune system? Check all that apply. Rig-I-like receptors have the advantage of recognizing viruses by interacting with their spike proteins TLR signaling includes NF-kB pathways to induce synthesis of proinflammatory cytokines TLR binds to dsDNA or ssRNA to induce interferon gene expression PRR induced secretion of proinflammatory cytokines and chemokines have local and systemic effects PRR induces innate immunity; phagocytosis, inflammation, type I interferon production, and regulate adaptive immunity; DC maturation, costimulatory molecules, type I interferon
The mechanism of cross-presentation by dendritic cells is an essential pathway for generating CD8 T cell responses to some intracellular pathogens. If this pathway did not exist, we would be highly susceptible to: Intracellular pathogens that can survive inside macrophage endocytic vesicles Intracellular pathogens that are able to evade antibody responses Intracellular pathogens that do not infect and replicate in dendritic cells Intracellular pathogens that can spread from cell to cell by inducing cell fusion Intracellular pathogens that infect and replicate in red blood cells
A patient has contracted an upper respiratory infection caused by a virus. Her initial adaptive immune response to the virus is due to what mechanism of immune surveillance?a. The display of viral antigens by naïve B-cells on class I MHC, which is then recognized by helper T-cells that then activate cytotoxic T-cells.b. The display of viral antigens on class I MHC, which is then displayed to sensitized naïve B-cells, leading to the production of antibodies.c. The display of viral antigens on class II MHC by a sensitized naïve B-cell, which is then activated by a helper T-cell primed to the same antigen to begin producing antibodies.d. The display of viral antigens on class I MHC, which is then displayed to helper T-cells, leading to the activation of naïve cytotoxic T-cells.
You have acquired a vial of immature B cells and would like to use them to generate and harvest antibodies against a specific pathogen of interest. You do not have access to T cells. How might you produce antibody from the B cells you have? Add high concentrations of TI-1 antigen to the culture medium. Add low concentrations of TI-2 antigen to the culture medium. Add high concentrations of TI-2 antigen to the culture medium. Add low concentrations of TI-1 antigen to the culture medium.
Which of the following statements is NOT correct? Group of answer choices -Natural killer cells are cytolytic lymphocytes that mediate ADCC -Neutrophils carry out phagocytosis of C3b-tagged particles -Macrophages carry out phagocytosis of C3b-tagged particles -Mast cells produce granules containing the cytotoxin perforin -B lymphocytes express a receptor for complement proteins
Helper T cells are affected by HIV, how come is this receptor key to the immune system? which line of defense are we referring to? How is it connected to the immune system and which line of defense? Hence, based on your prompt, how are cytokines linked to the defense mechanism of HIV virus? Do you know or can you explain the cascade of events dealing with PAMPS, TLRs, interferon? What do they have to do with the second line of defense?
Many cells in the human body have proteins on the surface that are able to interact with the receptors of helper T cells. Explain the mechanisms and why it is that such an interaction or signal does not usually result in an autoimmune reaction?
B cells express a complement receptor that binds to C3b cleavage products, such as iC3b and C3dg. When a B cell with an antigen receptor that specifically recognizes that pathogen also has its complement receptor stimulated because the pathogen is opsonized with these C3 fragments, B cell activation is greatly enhanced. Due to this mechanism, B cells can be activated by much lower concentrations of antigen (in this case, the pathogen) than if the antigen is devoid of complement components. This mechanism functions to: Ensure that pathogens are readily detected by the adaptive immune system before they replicate to high levels in the host Prevent B cells from being activated in response to antigens that are not pathogens Allow B cells to phagocytose the pathogen and help destroy it Induce increased rounds of B cell replication to make more pathogen-specific B cells Allow the B cell to block pathogen replication by interfering with multiple pathogen surface functions
Create a concept map that describes antibodies using the following terms: Antibodies Agglutination Antibody-dependent cell-mediated cytotoxicity (ADDC) Antigens Antigen-stimulated B cells Complement activation IgA IgD IgE IgG IgM Inflammation Neutralization Phagocytosis Plasma cells Secreted immunoglobulins
Put a case forward for the importance of antigen specific CD4+ T helper cells, relative to other T cells. Refer to their respective functions in your answer.