What is the lipid-water partition coefficient of the drug below? Drug AMB Initial volume of water and concentration of drug in the water layer = Volume of octanol added to the water layer Concentration of the drug in the lipid layer 350 ml (25%) 150 ml 10%
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- The doctor ordered Claforan 1400mg IM every 12 hours. The directions for the 2 gm vial state: Add 5 mL of diluent to yield an approximate concentration of 360mg/mL. How many mL will you give?Consider the following from the Ampicillin for Injection, USP package insert: For Intramuscular Use: Label Claim 250mg 500mg 1g 2g Amount of Diluent (mL) Approx. Volume (ml) 0.9 1.7 3.4 6.8 1 2 4 8 a) What is the amount of diluent needed to reconstitute a 1 g vial? b) What is the powder volume for a 1 g vial of ampicillin? Approx. Concentration (mg/mL) 250 250 250 250 Later in the package insert you see: For Direct Intravenous Use: Add 5 mL Sterile Water for Injection or Bacteriostatic Water for Injection to the 250 and 500 mg vials and administer slowly over a 3 to 5-minute period. Ampicillin for Injection, 1 g or 2 g, may also be given by direct intravenous administration. Dissolve in 7.4 or 14.8 mL Sterile Water for Injection or Bacteriostatic Water for Injection, respectively, and administer slowly over at least 10 to 15 minutes. c) What is the amount of diluent needed to reconstitute a 1 g vial of ampicillin for direct IV injection d) What is the total amount of volume that will…Volume Base: Additives Concentration Potassium Acetate 2 mEq/mL Dose Ordered Volume (mL) mL 30 mEq 12.5 mL Sodium Chloride 4 mEq/mL 50 mEq mL Ca Gluconate 0.465 mEq/mL 8 mEq 322 10 mL MVI-12 10 mL mL Famotidine 10 mg/mL 40 mg LI5. mL Volume Additives: mL Final Volume: Calculate the amount of Sterile Water for Injection needed to qs the total volume to 1,000 mL. mL Sterile Water: mL How many mLs should you remove from your Dextrose 70% bag? ccess Code Inside ources on Evolve
- 1&1/2 tsp po BID x 14 days #QS How many milliliters should the pharmacy dispense?Streptomycin sulfate 400 mg IM daily is ordered for a child weighing 77lbs. The recommended dosage is 20-40 mg/kg/day once daily. A 1 gram vial of streptomycin sulfate is available in powdered form with the following instructions: Dilution with 1.8 mL of sterile water will yield 400mg per mL. If safe, how many mLs will you give?