The plant toxin fluoroacetate (F-CH2COO−) is easily converted to fluorocitrate when an animal ingests the plant. The enzyme aconitase has a high affinity for the 2-fluorocitrate molecule. Consider the purpose of this enzyme and speculate as to why the reaction to produce isocitrate does not occur as planned. Why is fluoroacetate considered a poison? [Hint: Fluorine is more electronegative than oxygen.]
The plant toxin fluoroacetate (F-CH2COO−) is easily converted to fluorocitrate when an animal ingests the plant. The enzyme aconitase has a high affinity for the 2-fluorocitrate molecule. Consider the purpose of this enzyme and speculate as to why the reaction to produce isocitrate does not occur as planned. Why is fluoroacetate considered a poison? [Hint: Fluorine is more electronegative than oxygen.]
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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The plant toxin fluoroacetate (F-CH2COO−) is easily converted to fluorocitrate when an animal
ingests the plant. The enzyme aconitase has a high affinity for the 2-fluorocitrate molecule.
Consider the purpose of this enzyme and speculate as to why the reaction to produce isocitrate
does not occur as planned. Why is fluoroacetate considered a poison? [Hint: Fluorine is more
electronegative than oxygen.]
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