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The following diagram illustrates the process of fragment-based drug discovery Binding site her Optimise Sereen for tt ligand Soeen fer 2nd ligand Pretein Pretein Potein Optimise Link Pretein Protein Protein 14. What are the fragments labelled A and B known as? a, Analogs b. Conformers c. Epitopes d. Pharmacophores ni afomva a lo nolbubay qu 15. Which of the following statements is true? bruag bba. Parallel synthesis involves synthesis of a mixture of compounds in each reaction ve b. Parallel synthesis involves synthesis of a single compound in each reaction vessel nd in each reaction d. Parallel synthesis requires the use of a linker which must be cleaved at the end of c. Combinatorial synthesis involves synthesis of a single compo ni ord ni ba स स हो 5. Which of the following is not a requirement for a linker used in solid phase synthesis anls a. The linker must be covalently bound to the solid support beng b. The bond between linker and starting material must be stable to the reaction co the solid phase synthesis c. The linker must contain a protecting groupm od as bjoe oilyodie oh bos d. The bond to the linker must be easily cleaved at the end of the synthesis anoitibnoo oviw 15 B.

The following diagram illustrates the process of fragment-based drug discovery Binding site her Optimise Sereen for tt ligand Soeen fer 2nd ligand Pretein Pretein Potein Optimise Link Pretein Protein Protein 14. What are the fragments labelled A and B known as? a, Analogs b. Conformers c. Epitopes d. Pharmacophores ni afomva a lo nolbubay qu 15. Which of the following statements is true? bruag bba. Parallel synthesis involves synthesis of a mixture of compounds in each reaction ve b. Parallel synthesis involves synthesis of a single compound in each reaction vessel nd in each reaction d. Parallel synthesis requires the use of a linker which must be cleaved at the end of c. Combinatorial synthesis involves synthesis of a single compo ni ord ni ba स स हो 5. Which of the following is not a requirement for a linker used in solid phase synthesis anls a. The linker must be covalently bound to the solid support beng b. The bond between linker and starting material must be stable to the reaction co the solid phase synthesis c. The linker must contain a protecting groupm od as bjoe oilyodie oh bos d. The bond to the linker must be easily cleaved at the end of the synthesis anoitibnoo oviw 15 B.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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The following diagram illustrates the process of fragment-based drug discovery Đinding site her Sereen For tst ligand Sogen fer 2nd ligand Optimise Pretein Protein Protein A B. Optimise Link Pretein Protein Protein 14. What are the fragments labelled A and B known as? nhsioiyg onolisubiour a. Analogs b. Conformers c. Epitopes d. Pharmacophores afomya ado nol quoig 15. Which of the following statements is true? aloid s hoo bruage bb a, Parallel synthesis involves synthesis of a mixture of compounds in each reaction ves b. Parallel synthesis involves synthesis of a single compound in each reaction vessel c. Combinatorial synthesis involves synthesis of a single compound in each reaction w d. Parallel synthesis requires the use of a linker which must be cleaved at the end of badtode au of elist brucgnca a bias oilyxoctep sis ess1eriweulbre oviv niprif g ab 6. Which of the following is not a requirement for a linker used in solid phase synthesis beng nltas al a. The linker must be covalently bound to the solid support b. The bond between linker and starting material must be stable to the reaction con the solid phase synthesis c. The linker must contain a protecting group m rod as bioe pilvodie ot d. The bond to the linker must be easily cleaved at the end of the synthesis anoitibnoo oviv 1sb
Transcribed Image Text:The following diagram illustrates the process of fragment-based drug discovery Đinding site her Sereen For tst ligand Sogen fer 2nd ligand Optimise Pretein Protein Protein A B. Optimise Link Pretein Protein Protein 14. What are the fragments labelled A and B known as? nhsioiyg onolisubiour a. Analogs b. Conformers c. Epitopes d. Pharmacophores afomya ado nol quoig 15. Which of the following statements is true? aloid s hoo bruage bb a, Parallel synthesis involves synthesis of a mixture of compounds in each reaction ves b. Parallel synthesis involves synthesis of a single compound in each reaction vessel c. Combinatorial synthesis involves synthesis of a single compound in each reaction w d. Parallel synthesis requires the use of a linker which must be cleaved at the end of badtode au of elist brucgnca a bias oilyxoctep sis ess1eriweulbre oviv niprif g ab 6. Which of the following is not a requirement for a linker used in solid phase synthesis beng nltas al a. The linker must be covalently bound to the solid support b. The bond between linker and starting material must be stable to the reaction con the solid phase synthesis c. The linker must contain a protecting group m rod as bioe pilvodie ot d. The bond to the linker must be easily cleaved at the end of the synthesis anoitibnoo oviv 1sb
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