sentences, Describe how the process of receptor desensitization leads to drug tolerance
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In a few sentences, Describe how the process of receptor desensitization leads to drug tolerance
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- Describe how the process of receptor desensitization leads to drug toleranceBriefly describe the significance of drug clearance. How it affects the maintenance dose of the drug? List the major superfamilies of receptors that are involved in signal transduction. How it represents the targets of clinically used drugs? Give some examplesWhat are some of the forces that control the strength of interaction between a drug and a receptor?
- List the major superfamilies of receptors that are involved in signal transduction. How it represents the targets of clinically used drugs? Give some examples.Many drugs and physiological mechanisms operate, directly or indirectly, by influencing [Ca2+]I, second messenger system, protein kinase and nuclear receptor. Discuss in detail on how the above interaction shows therapeutic effect by using any reference drug as an examplIn the light of the mechanisms of signal transduction pathways, describe how: 1. the immune system is alerted and responds 2. immune responses against infected cells can lead to organ failure
- How does ligand binding, and voltage changes regulate specific types of ion channels? Provide examples of different drugs action on such targets by giving discussing briefly their mechanism of action.Can you please explain the Mechanism of action of Sertraline? Please answer at your own easy words. Answer should be to the point. Please don't use AI for answering this question.Drugs bind to receptor and give response to the body. What type of binding involve in this process ?
- How will you exploit the effector proteins of Type 3 and Type 4 secretion systems to develop novel therapeutics and drugs. Please be specific to Type 3and 4 systems, respectively. Please give 10 key points.Halle Zingiber has been granted refugee status in this country. He has had to leave his wife and two children in Ethiopia. He is severely depressed and is receiving treatment with the tricyclic depressant, nortriptyline. No effects were reported when standard doses of the drug (25 mg tds) were used. His doctor increased the dose many-fold to 200 mg/day a dose, which is inducing effects. Can you explain Halle’s unusual response to therapy?Describe the role of receptor sites in drug action.