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- a. Some of the acetyl-CoA used in the citric acid cycle is produced from pyruvate. List the reactants and products of this reaction. The reactants are pyruvate and The products are acetyl-CoA and In the process, a(n) is to b. Name an enzyme complex that catalyzes this reaction and list its negative effectors. is the enzyme complex that catalyzes this reaction. Its negative effectors are andA. What would be the effect of barbiturate abuse on oxidative phosphorylation ? B. What is the biochemical basis of carbon monoxide fatility?Discuss the metabolic control for HMG CoA reductase synthesis and activity
- Considering the metabolic disorder "Ethanol Sensitivity". Which of the following therapeutic approaches could result in improvement for an individual with this disorder? (Select 2 answers) O Pharmacological competitive inhibition of Ethanol Dehydrogenase O Pharmacological alloseteric inhibition of cytosolic acetylaldehyde dehydrogenase O Pharmacological activation of cytosolic aldehyde dehydrogenase O Pharmacological uncompetitive inhibition of mitochondrial acetylaldehyde dehydrogenasethese are KT values. Which transporter that is a GLUT will transport glucose from blood which is 5nm at the maximum or Vmax? Is it (GLUT 11,KT= 0.1M), (is it GLUT1, KT = 3nm), (is it GLUT 2, KT= 17nm), (or GLUT 4, KT = 5nm)Show sequentially, the total ATP Yield and the net ATP Yield in the complete oxidation of Glucose (from Glycolysis to Oxidative Phosphorylation) in the Muscle and Heart Tissues of a man. Indicate the differences in the ATP yield in both tissues.
- glucose determination explain how it happensPredict which one of the five steps of the a-ketoglutarate dehydrogenase complex reaction is metabolically irreversible under physiological conditions and explain why.a) describe the overall reaction catalyzed by the pyruvate dehydrogenase Situational Problems I. Oxidative decarboxylation of pyruvate and the TCA cycle in muscles are stimulated by increased aerobic excrcise. These processes operate only when O, is present, although oxygen does not participate directly in these processes. Explain why oxidative decarboxylation of pyruvate is activated under aerobic conditions. For the answer: a) describe the overall reaction catalyzed by the pyruvate complex (PDH) and its regulation; b) outline the intermediates and enzymes of the TCA cycle; c) explain the relationship between the reactions of PDH and the TCA cycle and the respiratory chain.
- 27. Working at cross-purposes . Write a balanced equation showing the effect of simultaneous activation of glycogen phosphorylase and glycogen synthase. Include the reactions catalyzed by phosphoglucomutase and UDP-glucose pyrophosphorylase.Characterizing Glycolysis List the reactions of glycolysis that a. are energy consuming (under standard-stale conditions), b. are energy yielding (under standard-state conditions), c. consume ATP. d. yield ATP e. are strongly influenced by changes in concentration of substrate and product because of their molecularity. f. are at or near equilibrium in the erythrocyte (see Table 18.2).Correlate the importance of Citric Acid Cycle in maintaining the glucose hemeostasis.