Metabolic Differences between Muscle and Liver in a “Fight or Flight” Situation. During a “fight or flight” situation, the release of epinephrine promotes glycogen breakdown in the liver, heart, and skeletal muscle. The end product of glycogen breakdown in the liver is glucose; the end product in skeletal muscle is pyruvate. (a) What is the reason for the different products of glycogen breakdown in the two tissues? (b) What is the advantage to an organism that must fight or flee of these specific glycogen breakdown routes?

Metabolic Differences between Muscle and Liver in a “Fight or Flight” Situation. During a “fight or flight” situation, the release of epinephrine promotes glycogen breakdown in the liver, heart, and skeletal muscle. The end product of glycogen breakdown in the liver is glucose; the end product in skeletal muscle is pyruvate. (a) What is the reason for the different products of glycogen breakdown in the two tissues? (b) What is the advantage to an organism that must fight or flee of these specific glycogen breakdown routes?

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter22: Gluconeogenesis, Glycogen Metabolism, And The Pentose Phosphate Pathway

Section: Chapter Questions

Problem 5P

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In muscle tissue, the rate of conversion of glycogen to glucose 6-phosphate is determined by the ratio of phosphorylase a (active) to phosphorylase b (less active). Determine what happens to the rate of glycogen breakdown if a muscle preparation containing glycogen phosphorylase is treated with: (a) phosphorylase kinase and ATP; (b) PP1; (c) epinephrine
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