Question 2 (a) Given and Scara were given a task of synthesising (2-methylprop-1- enyl)cyclohexane 2 (A potential TB drug). After a brief discussion with each other, Given proposed Method A to synthesise 2 from cyclohexanecarbaldehyde 1 while Scara proposed Method B that started from hydroxymethylcyclohexane 3. When designing a synthetic route for drug molecule, you have to make sure the synthetic process is as efficient as possible (e.g. few synthetic steps, mostly making one product and more). O 1 THE A Ph Ph B 3 2 1. PCC 2. isopropyl magnesium vromide 3. H₂SO4 100 °C OH After analyzing both of these methods, draw any one possible product other than (2-methylprop-1-enyl)cyclohexane mechanistic details to support your answer
Question 2 (a) Given and Scara were given a task of synthesising (2-methylprop-1- enyl)cyclohexane 2 (A potential TB drug). After a brief discussion with each other, Given proposed Method A to synthesise 2 from cyclohexanecarbaldehyde 1 while Scara proposed Method B that started from hydroxymethylcyclohexane 3. When designing a synthetic route for drug molecule, you have to make sure the synthetic process is as efficient as possible (e.g. few synthetic steps, mostly making one product and more). O 1 THE A Ph Ph B 3 2 1. PCC 2. isopropyl magnesium vromide 3. H₂SO4 100 °C OH After analyzing both of these methods, draw any one possible product other than (2-methylprop-1-enyl)cyclohexane mechanistic details to support your answer
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter23: Amines
Section: Chapter Questions
Problem 23.58P
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