Question 2(a) Given and Scara were given a task of synthesising (2-methylprop-1-enyl)cyclohexane 2 (Apotential TB drug). After a brief discussion with each other, Given proposed Method A tosynthesise 2 from cyclohexanecarbaldehyde 1 while Scara proposed Method B that startedfrom hydroxymethylcyclohexane 3. When designing a synthetic route for drug molecule,you have to make sure the synthetic process is as efficient as possible (e.g. few syntheticsteps, mostly making one product and more).(1)Tnunum1THFAPhPhPhB1. PCC2. isopropylmagnesiumvromide3. H₂SO4100 °COHUsing curly arrows, provide full mechanistic details to explain how method A willproceed.

The reaction in step A is an example of wittig reaction, where an alkene is produced from aldehyde.

Answered: (i) June 1 THF A Ph Ph Ph B 3 1. PCC 2.…

(i) June 1 THF A Ph Ph Ph B 3 1. PCC 2. isopropyl magnesium vromide 3. H₂SO4 100 °C .OH Using curly arrows, provide full mechanistic details to explain how method A will proceed.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question 2 (a) Given and Scara were given a task of synthesising (2-methylprop-1- enyl)cyclohexane 2 (A potential TB drug). After a brief discussion with each other, Given proposed Method A to synthesise 2 from cyclohexanecarbaldehyde 1 while Scara proposed Method B that started from hydroxymethylcyclohexane 3. When designing a synthetic route for drug molecule, you have to make sure the synthetic process is as efficient as possible (e.g. few synthetic steps, mostly making one product and more). 1 THF A Ph Ph B 3 1. PCC 2. isopropyl magnesium vromide 3. H₂SO4 100 °C OH After analyzing both of these methods, draw any one possible alkene product other than (2-methylprop-1-enyl)cyclohexane 2?Use mechanistic details to support your answer
(a) Given and Scara were given a task of synthesising (2-methylprop-1- enyl)cyclohexane 2 (A potential TB drug). After a brief discussion with each other, Given proposed Method A to synthesise 2 from cyclohexanecarbaldehyde 1 while Scara proposed Method B that started from hydroxymethylcyclohexane 3. When designing a synthetic route for drug molecule, you have to make sure the synthetic process is as efficient as possible (e.g. few synthetic steps, mostly making one product and more). THF A Ph Ph Ph B 3 1. PCC 2. isopropyl magnesium vromide 3. H₂SO4 100 °C OH Method B is not preferred synthetic route due to the number of steps involve (3 steps vs 1 step for Method A). What else is making method A unfavorable synthetic method? Use curly arrows to explain this effect. (Ctrl) -
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