Interpret the figure to explain how histidine and aspartate make serine a better nucleophile.  a.) histidine pulls a proton away from serine  aspartate pulls a proton away from histidine  b.) histidine pulls a proton away from serine aspartate donates a proton to histidine  c.)histidine donates a proton to serine aspartate pulls a proton away from serine d.) histidine donates a proton to serine  aspartate donates a proton to histidine

Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN:9781133893943
Author:ESTRIDGE
Publisher:ESTRIDGE
Chapter6: Basic Clinical Chemistry
Section6.1: Introduction To Clinical Chemistry
Problem 9RQ
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Interpret the figure to explain how histidine and aspartate make serine a better nucleophile. 

a.) histidine pulls a proton away from serine 

aspartate pulls a proton away from histidine 

b.) histidine pulls a proton away from serine

aspartate donates a proton to histidine 

c.)histidine donates a proton to serine

aspartate pulls a proton away from serine

d.) histidine donates a proton to serine 

aspartate donates a proton to histidine

 

Asp102
H-N
His57
Ser195
NH-O
P1
HN
P1'
amide bond
(substrate)
Transcribed Image Text:Asp102 H-N His57 Ser195 NH-O P1 HN P1' amide bond (substrate)
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