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For a patient with a glucose 6-phosphate dehydrogenase deficiency, suffering from the acute onset of hypoxia and anemia, which of the following is the most likely to happen to the red blood cells and lead to anemia?
a.
The increased presence of methemoglobin in the blood
b.
The decreased production of hemoglobin during RBC development
c.
The premature destruction of RBCs in the circulation
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- Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate? a. Glucose b. Oxaloacetate c. acetyl-CoA d. Lactate How does RBC's having no mitochondria do with this?Vitamin B12 cannot be produced by the human body but instead must be obtained from your diet. A patient has a diagnosis of pernicious anemia (Megaloblastic anemia). Explain the most common underlying cause of this disorder and explain how it is treated?Hemoglobin will bind oxygen and release CO2 in places where there is a higher concentration of O2, lower concentration of CO2, lower temperature and lower acidity (as it is in lungs) and will do the reverse – release oxygen and bind CO2 - in places where there is a lower concentration of O2, higher concentration of CO2, higher temperature and higher acidity (as it is in working muscles). True False While white blood cells never leave the circulation, red blood cells regularly leave it and travel by lymphatic system or find home in other tissues, e.g., lymph nodes, spleen, etc. True False Blood clotting (coagulation) is a complex process involving many factors and it exhibits positive feedback loops: many of the factors also stimulate production of their own precursors. B lymphocytes mature in the thymus while T lymphocytes mature in the bone marrow True False Antibodies are molecules on the surfaces of foreign…
- One way of reducing risk of cardiovascular disease is to ensure you are getting lots of antioxidants in your diet. What antioxidants would you recommend and not recommend for someone at risk of cardiovascular disease that is also on medication that interferes with their blood’s clotting mechanism? Explain the reasons for your recommendations in one to two paragraphs. Also, list three medical conditions that can alter a person's vitamin requirements. Explain what vitamin/s would be affected and how they should alter their dietary from normal recommendations.Explain why the hemoglobin concentration could appear deceptively high in a patient who is dehydrated, when in fact the patient does not have a hemoglobin or RBC excessXena lights a fire to keep warm, and cook his green root vegetables, which are extremely alkaline. Xena is so hungry, and she is eating all her green root vegetables making her blood quite alkaline for a short time. An example of the O2/Hb dissociation curve is provided below. The central blue line represents ‘normal blood’, and the typical affinity of Hb for O2. Referring to this figure will help you answer the following questions. Describe how the oxygen transporting capacity of haemoglobin will change for a short time in the presence of alkaline blood and explain the consequence of this change to the oxygen supply of peripheral tissues for this short time. Justify your answers.
- Hyperglycemia associated with diabetes promotes a prothrombotic state by affecting a number of different steps in the clotting pathway. Which of the following would result in more rather than less clotting? Check all that apply. The correct answers reflect the effect of hyperglycemia on the clotting pathway! less conversion of plasminogen to plasmin 7 000000000 abnormally low number of platelets platelets more sensitive to thromboxane A2 elevated conversion of plasminogen to plasmin platelets less sensitive to thromboxane A2 low sensitivity to NO and PGI2 increased prothrombin in the blood increased amount of fibrinogen in the blood less prothrombin in the blood abnormally high number of platelets less fibrinogen in the blood high sensitivity to NO and PGI2The anemia characterized by large and immature red blood cells is due to: O Folate and vit B12 deficiency O Folate toxicity and iron deficiency O Vitamin B1 and B2 deficiency O Iron and folate toxicityWhich of the following statements are true of red blood cells (RBCs)? (Read carefully and select all of the correct statements.) A. The protein hemoglobin contains the mineral iron. B. The life span of an RBC is about 60 days. C. Hemoglobin that has given up its oxygen is called debonded hemoglobin. D.RBCs have a life span of 120 days. E. The RBC is also know as erythrocyte. OF. The RBC is also known as thrombocytes. Type here to search D 5 CEN
- The content of ATP/ADP was considerably diminished in blood cells which was accompanied with the increase of time of bleeding as a result of hemostasis violation directly during the development of: A. reversible aggregation of thrombocytes B. irreversible aggregation of thrombocytes C. adhesion of thrombocytes D. hemocoagulation E. thromb's retractionWhich of the following proteins--when they become worn out--are responsible for the rupture of the RBC membrane? Select all that apply. spectrin hemoglobin carbonic anhydrase actin What happens to the heme portion of hemoglobin when a red blood cell dies? O it enters the small intestine where it is converted to bilirubin O it's converted to bilirubin which binds to albumin in the bloodstream O it's filtered by the kidneys and exits the body as urine O it's recycled and used to make hemoglobin for new cellsWhich of the following sentences is NOT true? A. Decreased blood oxygen levels triggers erythropoietin release B. Leptin decreases sensation of hunger C. Angiotensin II can cause vasoconstriction D. Albumin is the most abundant plasma protein E. Glucose is transported in blood dissolved in plasma F. Norepinephrine, epinephrine, and dopamine are secreted by islet of Langerhans