1. (6 points) The preparation of aspirin is achieved through acetylation of salicylic acid. Provide the full curved-arrow mechanism for this transformation. All starting materials, reagents, and products should be accounted for. + J. d OH H₂C OH salicylic acid CH3 acetic anhydride > H+ H3PO4 (conc.) 50 °C to 0 °C -H gt. CH3 OH acetylsalicylic acid (aspirin) i H₂C OH acetic acid

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The preparation of aspirin is achieved through acetylation of salicylic acid. Provide the full curved-arrow mechanism for this transformation. All starting materials, reagents, and products should be accounted for.

1. (6 points) The preparation of aspirin is achieved through acetylation of salicylic acid. Provide the full curved-arrow
mechanism for this transformation. All starting materials, reagents, and products should be accounted for.
+
J. d
OH
H₂C
OH
salicylic acid
CH3
acetic anhydride
> H+
H3PO4 (conc.)
50 °C to 0 °C
-H
gt.
CH3
OH
acetylsalicylic acid
(aspirin)
i
H₂C
OH
acetic acid
Transcribed Image Text:1. (6 points) The preparation of aspirin is achieved through acetylation of salicylic acid. Provide the full curved-arrow mechanism for this transformation. All starting materials, reagents, and products should be accounted for. + J. d OH H₂C OH salicylic acid CH3 acetic anhydride > H+ H3PO4 (conc.) 50 °C to 0 °C -H gt. CH3 OH acetylsalicylic acid (aspirin) i H₂C OH acetic acid
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