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Curren'S Math For Meds: Dosages & Sol

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter14: Formula Method

Section: Chapter Questions

Problem 38SST

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Question

Part 1
2
There have been
9
Part 2
8
chromosome
6
significant regions identified on
10
· LL
Image available for use under Creative Commons Attribution 2.5 Generic License. Sourced from:
https://commons.wikimedia.org/wiki/File:Manhattan Plot.png
12-
Attribution: Ikram MK et al (2010) Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo.
PLoS Genet. 2010 Oct 28;6(10):e1001184. doi:10.1371/journal.pgen.1001184.g001
Based on these results, what can we claim? Select any/all that apply
13
different chromosomes.
14
15-
There are at least 5 loci in the genome containing genes that influence microcirculation
The most highly associated SNP at the locus on chromosome 19 causes an increase in microcirculation
A locus on chromosome 19 is the most significantly associated with differences in microcirculation
Loss of function mutations in a least 5 genes contribute to variation in microcirculation

This question has two parts.
Below is a Manhattan plot from a GWAS investigating microcirculation (circulation of blood through the smallest blood
vessels). Changes in microcirculation can be correlated to increased risk of cardiovascular events. For our purposes we will
consider the -log10(P) of about 7 as the significance threshold.
15
10
- log10 (P)
2
Part 1
3
8
chromosome
6
- OL
·LL
Į
Image available for use under Creative Commons Attribution 2.5 Generic License. Sourced from:
https://commons.wikimedia.org/wiki/File:Manhattan
Plot.png
Attribution: Ikram MK et al (2010) Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo.
PLoS Genet. 2010 Oct 28;6(10):e1001184. doi:10.1371/journal.pgen.1001184.g001

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