(b) The hemoglobin subunits expressed in a growing fetus and adult mother are different from each other. The fetal y variant of the adult B subunit substitutes a Ser for one of the His residues that interacts with BPG in the central cavity between the ß subunits, reducing affinity for BPG. (i) Draw in oxygen binding curves below for the wild-type adult hemoglobin and the fetal hemoglobin containing the y variant. Make sure to label each curve. Fractional occupancy (f) lungs tissues 1.0₁ ALI 0.5- 50 pO₂ (torr) 100 (ii) Given how the mutation influences BPG binding, why do you think its advantageous for the fetus to carry this amino acid substitution? Provide a mechanistic explanation for your answer.
(b) The hemoglobin subunits expressed in a growing fetus and adult mother are different from each other. The fetal y variant of the adult B subunit substitutes a Ser for one of the His residues that interacts with BPG in the central cavity between the ß subunits, reducing affinity for BPG. (i) Draw in oxygen binding curves below for the wild-type adult hemoglobin and the fetal hemoglobin containing the y variant. Make sure to label each curve. Fractional occupancy (f) lungs tissues 1.0₁ ALI 0.5- 50 pO₂ (torr) 100 (ii) Given how the mutation influences BPG binding, why do you think its advantageous for the fetus to carry this amino acid substitution? Provide a mechanistic explanation for your answer.
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
Section: Chapter Questions
Problem 20P: Understanding the Mechanism of Hemolytic Anemia Genetic defects in glycolytic enzymes can have...
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