A decrease in blood glucose levels will, in the liver, lead to the inhibition, either directly or indirectly, of which of the following enzymatic activities? Select one: a. Lactate dehydrogenase b. Phosphofructokinase c. Pyruvate kinase d. Enolase
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- In what stage of catabolism does each of the following processes occur? a. cleavage of a protein with chymotrypsin b. oxidation of a fatty acid to acetyl CoA c. oxidation of malate to oxaloacetate with NAD +d. conversion of ADP to ATP with ATP synthase e. hydrolysis of starch to glucose with amylaseThe rate limiting and committed step of the pentose phosphate pathway is catalyzed by which of the following enzymes? A. Glucose-6-phosphate dehydrogenase B. Hexokinase C. 6-Phosphogluconate dehydrogenase D. TransketolaseMatch the enzyme to the reaction catalysed. Not all the enzymes have to be selected, and an enzyme may be used more than once. v Synthesizes phosphatidic acid A. Glycerol-3-phosphate dehydrogenase v Synthesizes triacylglycerol B. Glycerol kinase v Synthesizes acetoacetyl-CoA C. Acyl-CoA cholesterol acyl transferase v Synthesizes mevalonate D. Lipin v Synthesize 1,2 diacylglycerol E. Acyl transferase v Converts glycerol into glycerol-3-phosphate F. HMG-CoA reductase v Converts dihydroxyacetone phosphate into glycerol-3-phosphate G. Thiolase v Synthesize cholesterol-ester
- In the last step of glycolysis, phosphoenolpyruvate (PEP) is converted to pyruvate and during this reaction ATP is synthesized. Based on the fact that ATP is synthesized, which of the following enzymes would most likely catalyze this reaction? a. enolase b. pyruvate kinase c. aldolase d. pyruvate isomerase e. pyruvate dehydrogenaseFor each of the following conditions, state whether this condition would be occurring during gluconeogenesis, glycolysis, or both in liver cells. a. Transporting malate from the cytosol into the mitochondria. _____________ b. Transporting pyruvate from the cytosol into the mitochondria. _____________ c. We would have an increased (or increasing) concentration of F26BP. __________ d. Increased concentration of F6P.__________ e. Hexokinase IV (or glucokinase) is found in the nucleus of the cell. __________ f. The enzyme that synthesizes/breaks down F26BP is phosphorylated. __________ g. Elevated levels of glucagon in the blood. ____________Glucagon is released from the pancreas in response to low blood glucose levels. It regulates the opposing pathways of glycolysis and gluconeogenesis by altering levels of fructose 2,6-bisphosphate. If glucagon causes a decrease in fructose 2,6-bisphosphate, how does this increase blood glucose levels? Explain..
- Match the coenzymes and/or substrates with their corresponding glycolytic enzymes. Note that an enzyme can match with more than one coenzyme or substrate in the list. ATP NAD+ Dihydroxyacetone phosphate A. Glucose 1-dehydrogenase B. Phosphofructokinase-1 C. Glyceraldehyde 3-phosphate dehydrogenase D. ATPase E. Triose phosphate isomeraseGive the number of the following:a. number of acetyl-CoA that enters the TCA cycle for every 5 molecules of glucoseb. number of high-energy phosphate groups required for the complete formation of glucose during gluconeogenesisc. number of NADPH produced for each molecule of glucose in the pentose phosphate pathwayDesign a radiotracer experiment that would allow you to determine which proportion of glucose catabolism in a given tissue prepara- tion occurs through the pentose phosphate pathway and which pro- portion through glycolysis and the citric acid cycle. Assume that you can synthesize glucose labeled with 1"C in any desired position or combination of positions. Assume also that you can trap CO, after administration of labeled glucose and determine its radioactivity.
- One of the earliest responses to cellular injury is a rapid increase in the levels of enzymes in the pentose phosphate pathway. About ten days after an injury, levels of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in heart tissue are 20 to 30 times higher than normal. However the levels of glycolytic enzymes are only 10% to 20% of normal. Explain this phenomenon.CHOOSE THE CORRECT LETTER Which of the following reactions does NADH act as coenzyme?A. "glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate"B. pyruvate to acetyl-CoAC. isocitrate to a-ketoglutarateD. pyruvate to lactateWhich of the following regulatory mechanisms are used to regulate the enzyme activity of the pyruvate dehydrogenase complex (PDH)? 1) its activity is decreased by elevated levels of the products of the reaction via allosteric control 2) its activity can be modulated only through reversible covalent modification (phosphorylation/dephosphorylation) 3) insulin causes the complex to be phosphorylated, thus increases its activity 4) the complex is more active when dephosphorylated, a process triggered by insulin 5) the protein kinase that phosphorylates the PDH complex is sensitive to changes in the levels of ATP a) 2+3+5 b) 1+2+3 c) 1+3+5 d) 2+4+5